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    BIN3 bridging integrator 3 [ Homo sapiens (human) ]

    Gene ID: 55909, updated on 11-Apr-2024

    Summary

    Official Symbol
    BIN3provided by HGNC
    Official Full Name
    bridging integrator 3provided by HGNC
    Primary source
    HGNC:HGNC:1054
    See related
    Ensembl:ENSG00000147439 MIM:606396; AllianceGenome:HGNC:1054
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 13.5), adrenal (RPKM 7.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    See BIN3 in Genome Data Viewer
    Location:
    8p21.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (22620418..22669121, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (22894322..22943373, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22477931..22526634, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22435755-22436448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18994 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18997 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22439222-22439914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22442189-22442858 Neighboring gene PDZ and LIM domain 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22447071-22448071 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22454615-22455362 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22455363-22456110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18999 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22458799-22459676 Neighboring gene uncharacterized LOC107986876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27082 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:22462104-22462604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19003 Neighboring gene chromosome 8 open reading frame 58 Neighboring gene cell cycle and apoptosis regulator 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22483969-22484602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22485870-22486503 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22486504-22487136 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22488646-22489180 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22489181-22489715 Neighboring gene BIN3 intronic transcript 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22515470-22516064 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22516065-22516659 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:22526357-22526986 Neighboring gene CRISPRi-validated cis-regulatory element chr8.740 Neighboring gene uncharacterized LOC107986924 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22547791-22548696 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:22549417-22549612 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19006 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:22551019-22551182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22551227-22551872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19008 Neighboring gene uncharacterized LOC105379321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19009 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19010 Neighboring gene early growth response 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC14978

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytoskeletal anchor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    contributes_to lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cortical patch localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cytoskeleton-dependent cytokinesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in division septum assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in myoblast migration involved in skeletal muscle regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in plasma membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363046.2NP_001349975.1  bridging integrator 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC037459, BC009824, BM670487, CN427936, DA480525
      Consensus CDS
      CCDS87587.1
      UniProtKB/TrEMBL
      H7BYV6
      Related
      ENSP00000382859.4, ENST00000399977.8
      Conserved Domains (1) summary
      cl12013
      Location:7188
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. NM_018688.6NP_061158.1  bridging integrator 3 isoform 1

      See identical proteins and their annotated locations for NP_061158.1

      Status: REVIEWED

      Source sequence(s)
      AC037459, AC105046, BC009824, BM670487, DA480525
      Consensus CDS
      CCDS47825.1
      UniProtKB/Swiss-Prot
      Q9BVG2, Q9NQY0, Q9NVY9
      UniProtKB/TrEMBL
      Q53HW0
      Related
      ENSP00000276416.6, ENST00000276416.11
      Conserved Domains (1) summary
      cd07590
      Location:12236
      BAR_Bin3; The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 3

    RNA

    1. NR_156436.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC037459, AC105046, BC009824, BM670487, CR995147, DA480525

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      22620418..22669121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421995.1XP_047277951.1  bridging integrator 3 isoform X1

      Related
      ENSP00000430423.1, ENST00000519513.5
    2. XM_011544587.2XP_011542889.1  bridging integrator 3 isoform X2

      UniProtKB/TrEMBL
      E5RHU4
      Related
      ENSP00000429660.1, ENST00000520292.1
      Conserved Domains (1) summary
      cl12013
      Location:12118
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      22894322..22943373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360843.1XP_054216818.1  bridging integrator 3 isoform X1

    2. XM_054360845.1XP_054216820.1  bridging integrator 3 isoform X3

    3. XM_054360844.1XP_054216819.1  bridging integrator 3 isoform X2