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    ZNF395 zinc finger protein 395 [ Homo sapiens (human) ]

    Gene ID: 55893, updated on 28-Oct-2024

    Summary

    Official Symbol
    ZNF395provided by HGNC
    Official Full Name
    zinc finger protein 395provided by HGNC
    Primary source
    HGNC:HGNC:18737
    See related
    Ensembl:ENSG00000186918 MIM:609494; AllianceGenome:HGNC:18737
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PBF; PRF1; HDBP2; PRF-1; HDBP-2; HDRF-2; Si-1-8-14
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 29.1), placenta (RPKM 20.8) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZNF395 in Genome Data Viewer
    Location:
    8p21.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (28345590..28386460, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (28623756..28664627, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (28203107..28243977, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L5 pseudogene 22 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28175778-28176290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28176291-28176802 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27162 Neighboring gene prepronociceptin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28200887-28201454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28203430-28203930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:28205819-28206378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:28206379-28206938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28216758-28217258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28217259-28217759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28222946-28223446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27168 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:28241577-28241751 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19055 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19057 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27170 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27171 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:28268555-28269173 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:28269174-28269793 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:28277089-28277305 Neighboring gene RNA, U6 small nuclear 178, pseudogene Neighboring gene F-box protein 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27174

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: FBXO16

    Clone Names

    • DKFZp434K1210

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein 395
    Names
    HD gene regulatory region-binding protein 2
    HD-regulating factor 2
    Huntington's disease gene regulatory region-binding protein 2
    huntington disease gene regulatory region-binding protein 2
    papillomavirus regulatory factor 1
    papillomavirus regulatory factor PRF-1
    papillomavirus-binding factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018660.3NP_061130.1  zinc finger protein 395

      See identical proteins and their annotated locations for NP_061130.1

      Status: VALIDATED

      Source sequence(s)
      AI049727, AK023418, AK026076, AL137588, BC008870, BG249131, BG759384, BI917232, CB960515
      Consensus CDS
      CCDS6067.1
      UniProtKB/Swiss-Prot
      B3KUY7, D3DST4, Q6F6H2, Q9BY72, Q9H8N7, Q9NPB2, Q9NS57, Q9NS58, Q9NS59
      Related
      ENSP00000340494.5, ENST00000344423.10
      Conserved Domains (1) summary
      pfam15997
      Location:21109
      DUF4772; Domain of unknown function (DUF4772)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      28345590..28386460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      28623756..28664627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)