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    LENEP lens epithelial protein [ Homo sapiens (human) ]

    Gene ID: 55891, updated on 17-Jun-2024

    Summary

    Official Symbol
    LENEPprovided by HGNC
    Official Full Name
    lens epithelial proteinprovided by HGNC
    Primary source
    HGNC:HGNC:14429
    See related
    Ensembl:ENSG00000163352 MIM:607377; AllianceGenome:HGNC:14429
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LEP503
    Summary
    The ocular lens is a tissue of epithelial origin and devoid of blood vessels and nerves. Cells of the lens epithelium are responsible for the growth and maintenance of the lens through mitosis, protein synthesis, and active transport of ions and metabolites across the lens capsule. Lens epithelial protein is expressed exclusively in lens epithelial cells and may play a role in cell differentiation. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LENEP in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (154993586..154994321)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (154132942..154133677)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154966062..154966797)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microRNA 4258 Neighboring gene CDC28 protein kinase regulatory subunit 1B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154953875-154954472 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154955073-154955670 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154958088-154958777 Neighboring gene flavin adenine dinucleotide synthetase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154971857-154972809 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1375 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1379 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154977250-154977922 Neighboring gene zinc finger and BTB domain containing 7B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154980166-154980880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154982382-154983131 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154984631-154985378 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:154989823 Neighboring gene DC-STAMP domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    lens epithelial cell protein LEP503

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394530.1NP_001381459.1  lens epithelial cell protein LEP503

      Status: REVIEWED

      Source sequence(s)
      AL451085
      Consensus CDS
      CCDS1080.1
      UniProtKB/Swiss-Prot
      B5BUM1, Q5T1A4, Q9Y5L5
      Related
      ENSP00000376278.1, ENST00000392487.2
      Conserved Domains (1) summary
      pfam15221
      Location:161
      LEP503; Lens epithelial cell protein LEP503
    2. NM_018655.3NP_061125.1  lens epithelial cell protein LEP503

      See identical proteins and their annotated locations for NP_061125.1

      Status: REVIEWED

      Source sequence(s)
      AF268478, AL451085, BC069140, BM716801
      Consensus CDS
      CCDS1080.1
      UniProtKB/Swiss-Prot
      B5BUM1, Q5T1A4, Q9Y5L5
      Related
      ENSP00000357412.3, ENST00000368427.3
      Conserved Domains (1) summary
      pfam15221
      Location:161
      LEP503; Lens epithelial cell protein LEP503

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      154993586..154994321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      154132942..154133677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)