nfe2l1b nfe2 like bZIP transcription factor 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nfe2l1bprovided by ZNC
Official Full Name: nfe2 like bZIP transcription factor 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-120319-2
See related: Ensembl:ENSDARG00000076533 AllianceGenome:ZFIN:ZDB-GENE-120319-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular response to oxidative stress; cholesterol metabolic process; and regulation of transcription, DNA-templated. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in nucleus. Orthologous to human NFE2L1 (NFE2 like bZIP transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (28854404..28866179)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (28739508..28751277)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: endoplasmic reticulum membrane sensor NFE2L1b; nuclear factor erythroid 2-related factor 1

Names: Nrf1b; nuclear factor, erythroid 2-like 1b; nuclear factor, erythroid derived 2,-like 1b; nuclear factor-like 1b protein; zmp:0000000800

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278842.1 → NP_001265771.1 endoplasmic reticulum membrane sensor NFE2L1b

See identical proteins and their annotated locations for NP_001265771.1

Status: PROVISIONAL

Source sequence(s)

JX867116

UniProtKB/TrEMBL

A0A8M1P4I1, L0ANA2

Conserved Domains (1) summary

cd14720
Location:677 → 744

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

28854404..28866179

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017358462.2 → XP_017213951.1 nuclear factor erythroid 2-related factor 1 isoform X1

UniProtKB/TrEMBL

A0A8M1P4I1, L0ANA2

Conserved Domains (1) summary

cd14720
Location:677 → 744

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
XM_005156246.4 → XP_005156303.1 nuclear factor erythroid 2-related factor 1 isoform X2

UniProtKB/TrEMBL

A0A8M2B2A3, U3JAR7

Related

ENSDARP00000127336.1, ENSDART00000152991.3

Conserved Domains (1) summary

cd14720
Location:601 → 668

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain