U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    ZC3H15 zinc finger CCCH-type containing 15 [ Homo sapiens (human) ]

    Gene ID: 55854, updated on 9-Jun-2024

    Summary

    Official Symbol
    ZC3H15provided by HGNC
    Official Full Name
    zinc finger CCCH-type containing 15provided by HGNC
    Primary source
    HGNC:HGNC:29528
    See related
    Ensembl:ENSG00000065548 MIM:619704; AllianceGenome:HGNC:29528
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DFRP1; HT010; LEREPO4; MSTP012
    Summary
    Enables RNA binding activity and cadherin binding activity. Involved in positive regulation of GTPase activity. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bone marrow (RPKM 44.3), brain (RPKM 30.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZC3H15 in Genome Data Viewer
    Location:
    2q32.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (186486260..186509361)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (186975546..186998651)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (187350987..187374088)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 28 pseudogene 3 Neighboring gene uncharacterized LOC105373785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16843 Neighboring gene divergent-paired related homeobox pseudogene 1 Neighboring gene uncharacterized LOC124907920 Neighboring gene uncharacterized LOC107985784

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables cadherin binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger CCCH domain-containing protein 15
    Names
    DRG family-regulatory protein 1
    likely ortholog of mouse immediate early response erythropoietin 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018471.3NP_060941.2  zinc finger CCCH domain-containing protein 15

      See identical proteins and their annotated locations for NP_060941.2

      Status: VALIDATED

      Source sequence(s)
      AL040058, BC021102
      Consensus CDS
      CCDS42791.1
      UniProtKB/Swiss-Prot
      B4DMW2, D3DPG7, Q5QTQ4, Q8WU90, Q8WZ06, Q9NUZ3, Q9NZ37, Q9P079
      UniProtKB/TrEMBL
      B7Z592
      Related
      ENSP00000338788.6, ENST00000337859.11
      Conserved Domains (3) summary
      smart00356
      Location:99125
      ZnF_C3H1; zinc finger
      COG5252
      Location:1325
      COG5252; Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only]
      pfam16543
      Location:230312
      DFRP_C; DRG Family Regulatory Proteins, Tma46

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      186486260..186509361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      186975546..186998651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)