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    UTP6 UTP6 small subunit processome component [ Homo sapiens (human) ]

    Gene ID: 55813, updated on 17-Jun-2024

    Summary

    Official Symbol
    UTP6provided by HGNC
    Official Full Name
    UTP6 small subunit processome componentprovided by HGNC
    Primary source
    HGNC:HGNC:18279
    See related
    Ensembl:ENSG00000108651 AllianceGenome:HGNC:18279
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCA66; C17orf40
    Summary
    Predicted to enable snoRNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lymph node (RPKM 15.1), testis (RPKM 14.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See UTP6 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (31860904..31901708, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (32806760..32847572, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (30187923..30228727, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:30088656-30089855 Neighboring gene GPR160 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:30114922-30115422 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:30127927-30128120 Neighboring gene Sharpr-MPRA regulatory region 4911 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:30185250-30185924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8414 Neighboring gene coordinator of PRMT5 and differentiation stimulator Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12020 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:30228395-30228986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12021 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:30243727-30244384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:30244385-30245040 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:30264117-30264702 Neighboring gene SUZ12 polycomb repressive complex 2 subunit Neighboring gene RNA, 5S ribosomal pseudogene 437 Neighboring gene SUZ12 PRS4 recombination region Neighboring gene uncharacterized LOC124903972 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:30333403-30334325 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8417 Neighboring gene leucine rich repeat containing 37B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of Pwp2p-containing subcomplex of 90S preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    U3 small nucleolar RNA-associated protein 6 homolog
    Names
    UTP6, small subunit (SSU) processome component, homolog
    hepatocellular carcinoma-associated antigen 66
    multiple hat domains protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018428.3NP_060898.2  U3 small nucleolar RNA-associated protein 6 homolog

      See identical proteins and their annotated locations for NP_060898.2

      Status: VALIDATED

      Source sequence(s)
      AC004253, AF334386, BC015454, BC035325
      Consensus CDS
      CCDS11269.1
      UniProtKB/Swiss-Prot
      Q8IX96, Q96BL2, Q9NQ91, Q9NYH9
      UniProtKB/TrEMBL
      B3KQ21
      Related
      ENSP00000261708.4, ENST00000261708.9
      Conserved Domains (2) summary
      COG5191
      Location:1222
      COG5191; Uncharacterized conserved protein, contains HAT (Half-A-TPR) repeat [General function prediction only]
      pfam08640
      Location:981
      U3_assoc_6; U3 small nucleolar RNA-associated protein 6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      31860904..31901708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524997.4XP_011523299.1  U3 small nucleolar RNA-associated protein 6 homolog isoform X1

      UniProtKB/TrEMBL
      B3KQ21
      Conserved Domains (2) summary
      COG5191
      Location:1222
      COG5191; Uncharacterized conserved protein, contains HAT (Half-A-TPR) repeat [General function prediction only]
      pfam08640
      Location:981
      U3_assoc_6; U3 small nucleolar RNA-associated protein 6
    2. XM_047436390.1XP_047292346.1  U3 small nucleolar RNA-associated protein 6 homolog isoform X2

      UniProtKB/TrEMBL
      B3KX32
    3. XM_047436391.1XP_047292347.1  U3 small nucleolar RNA-associated protein 6 homolog isoform X3

      UniProtKB/TrEMBL
      B4DSL9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      32806760..32847572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316654.1XP_054172629.1  U3 small nucleolar RNA-associated protein 6 homolog isoform X1

      UniProtKB/TrEMBL
      B3KQ21
    2. XM_054316655.1XP_054172630.1  U3 small nucleolar RNA-associated protein 6 homolog isoform X2

      UniProtKB/TrEMBL
      B3KX32
    3. XM_054316656.1XP_054172631.1  U3 small nucleolar RNA-associated protein 6 homolog isoform X3

      UniProtKB/TrEMBL
      B4DSL9