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    H2AJ H2A.J histone [ Homo sapiens (human) ]

    Gene ID: 55766, updated on 5-May-2024


    Official Symbol
    H2AJprovided by HGNC
    Official Full Name
    H2A.J histoneprovided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000246705 AllianceGenome:HGNC:14456
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a replication-independent histone that is a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member. This gene also encodes an antimicrobial peptide with antibacterial and antifungal activity.[provided by RefSeq, Oct 2015]
    Broad expression in testis (RPKM 28.0), prostate (RPKM 26.6) and 24 other tissues See more
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    Genomic context

    See H2AJ in Genome Data Viewer
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (14774405..14778002)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (14651754..14655351)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (14927339..14930936)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene GUCY2C antisense RNA 1 Neighboring gene uncharacterized LOC105369669 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:14922691-14923286 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:14923287-14923883 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:14926759-14927676 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:14927677-14928593 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4276 Neighboring gene H4 histone 16 Neighboring gene WW domain binding protein 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6057 Neighboring gene chromosome 12 open reading frame 60 Neighboring gene single-pass membrane protein with coiled-coil domains 3

    Genomic regions, transcripts, and products


    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018


    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, histone H2A.J, is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
    Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information


    Clone Names

    • MGC921, FLJ10903, FLJ52230

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    enables nucleosomal DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    part_of nucleosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info

    General protein information

    Preferred Names
    histone H2A.J
    H2A histone family member J
    buforin I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177925.5NP_808760.1  histone H2A.J

      See identical proteins and their annotated locations for NP_808760.1

      Status: REVIEWED

      Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
      Source sequence(s)
      Consensus CDS
      Q9BTM1, Q9NV63
      ENSP00000438553.1, ENST00000544848.3
      Conserved Domains (1) summary
      PTZ00017; histone H2A; Provisional


    1. NR_027716.3 RNA Sequence

      Status: REVIEWED

      Transcript Variant: This variant (2) lacks an alternate segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC010168, KF455607

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly


    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0


    1. NC_060936.1 Alternate T2T-CHM13v2.0

      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_018267.2: Suppressed sequence

      NM_018267.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and it is a nonsense-mediated mRNA decay (NMD) candidate.