ASF1B anti-silencing function 1B histone chaperone [Homo sapiens (human)] - Gene

Summary

Official Symbol: ASF1Bprovided by HGNC
Official Full Name: anti-silencing function 1B histone chaperoneprovided by HGNC
Primary source: HGNC:HGNC:20996
See related: Ensembl:ENSG00000105011 MIM:609190; AllianceGenome:HGNC:20996
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CIA-II
Summary: This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly. [provided by RefSeq, Jul 2008]
Expression: Biased expression in testis (RPKM 18.2), lymph node (RPKM 12.4) and 13 other tissues See more
Orthologs: all
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Genomic context

Location:: 19p13.12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (14119512..14136589, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (14246124..14263201, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (14230324..14247401, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ASF1B is an essential prognostic indicator linked to the growth and resistance characteristics of bladder cancer.
Title: ASF1B is an essential prognostic indicator linked to the growth and resistance characteristics of bladder cancer.
CIA-II is associated with lower-grade glioma survival and cell proliferation.
Title: CIA-II is associated with lower-grade glioma survival and cell proliferation.
ASF1B, as an Independent Prognostic Biomarker, Correlates with Immune Infiltrates in Hepatocellular Carcinoma.
Title: ASF1B, as an Independent Prognostic Biomarker, Correlates with Immune Infiltrates in Hepatocellular Carcinoma.
miR-24-3p Regulates Epithelial-Mesenchymal Transition and the Malignant Phenotype of Pancreatic Adenocarcinoma by Regulating ASF1B Expression.
Title: miR-24-3p Regulates Epithelial-Mesenchymal Transition and the Malignant Phenotype of Pancreatic Adenocarcinoma by Regulating ASF1B Expression.
The interaction between ASF1B and TLK1 promotes the malignant progression of low-grade glioma.
Title: The interaction between ASF1B and TLK1 promotes the malignant progression of low-grade glioma.
The circCDK17/miR-122-5p/ASF1B axis regulates the progression of cervical cancer.
Title: The circCDK17/miR-122-5p/ASF1B axis regulates the progression of cervical cancer.
Antisilencing function 1B promotes the progression of pancreatic cancer by activating cMyc.
Title: Anti‑silencing function 1B promotes the progression of pancreatic cancer by activating c‑Myc.
Downregulation of ASF1B inhibits tumor progression and enhances efficacy of cisplatin in pancreatic cancer.
Title: Downregulation of ASF1B inhibits tumor progression and enhances efficacy of cisplatin in pancreatic cancer.
Involvement of elevated ASF1B in the poor prognosis and tumorigenesis in pancreatic cancer.
Title: Involvement of elevated ASF1B in the poor prognosis and tumorigenesis in pancreatic cancer.
ASF1B enhances migration and invasion of lung cancers cell via regulating the P53-mediated epithelial-mesenchymal transformation (EMT) signaling pathway.
Title: ASF1B enhances migration and invasion of lung cancers cell via regulating the P53-mediated epithelial-mesenchymal transformation (EMT) signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables histone chaperone activity	IDA Inferred from Direct Assay more info	PubMed
enables histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication-dependent chromatin assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication-dependent chromatin assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	NAS Non-traceable Author Statement more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in transcription elongation-coupled chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histone chaperone ASF1B

Names: ASF1 anti-silencing function 1 homolog B; CCG1-interacting factor A-II; anti-silencing function protein 1 homolog B; hAsf1; hAsf1b; hCIA-II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.