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    PPP4R3A protein phosphatase 4 regulatory subunit 3A [ Homo sapiens (human) ]

    Gene ID: 55671, updated on 7-Jul-2024

    Summary

    Official Symbol
    PPP4R3Aprovided by HGNC
    Official Full Name
    protein phosphatase 4 regulatory subunit 3Aprovided by HGNC
    Primary source
    HGNC:HGNC:20219
    See related
    Ensembl:ENSG00000100796 MIM:610351; AllianceGenome:HGNC:20219
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    smk1; FLFL1; PP4R3; SMEK1; smk-1; PP4R3A; MSTP033; KIAA2010
    Summary
    Predicted to act upstream of or within positive regulation of gluconeogenesis and protein dephosphorylation. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bone marrow (RPKM 27.7), testis (RPKM 19.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PPP4R3A in Genome Data Viewer
    Location:
    14q32.12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (91457508..91510554, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (85682749..85735802, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (91923852..91976898, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:91884645-91885289 Neighboring gene COX assembly mitochondrial protein homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8921 Neighboring gene CCDC88C divergent transcript Neighboring gene uncharacterized LOC124903361 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8923 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:91963914-91964077 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:91975254-91975905 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:91975906-91976556 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6030 Neighboring gene uncharacterized LOC101928957 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:92023369-92023910 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:92023911-92024452 Neighboring gene NANOG hESC enhancer GRCh37_chr14:92036233-92036734 Neighboring gene cation channel sperm associated auxiliary subunit beta Neighboring gene RNA polymerase III subunit G pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    part_of protein phosphatase 4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 4 regulatory subunit 3A
    Names
    SMEK homolog 1, suppressor of mek1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284280.2NP_001271209.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform 1

      See identical proteins and their annotated locations for NP_001271209.1

      Status: VALIDATED

      Source sequence(s)
      AB095930, AI608781, BC022778, BC028088
      Consensus CDS
      CCDS9895.1
      UniProtKB/TrEMBL
      G3V5Z3
      Related
      ENSP00000450864.1, ENST00000554684.5
      Conserved Domains (3) summary
      pfam04802
      Location:166357
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:765
      PH-like; Pleckstrin homology-like domain
      cl26969
      Location:325402
      Vitellogenin_N; Lipoprotein amino terminal region
    2. NM_001284281.2NP_001271210.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform 3

      See identical proteins and their annotated locations for NP_001271210.1

      Status: VALIDATED

      Source sequence(s)
      AI608781, BC028088, BC038932
      Consensus CDS
      CCDS61532.1
      UniProtKB/Swiss-Prot
      Q6IN85
      UniProtKB/TrEMBL
      Q8N6W1
      Related
      ENSP00000450891.1, ENST00000555462.5
      Conserved Domains (3) summary
      pfam04802
      Location:66118
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:798
      PH-like; Pleckstrin homology-like domain
      cl26969
      Location:86163
      Vitellogenin_N; Lipoprotein amino terminal region
    3. NM_001366432.2NP_001353361.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL133153
      Consensus CDS
      CCDS91918.1
      UniProtKB/Swiss-Prot
      Q69YK6, Q6IN85, Q86U23, Q86YI7, Q8IVG1, Q9H3F1, Q9H7U8, Q9NV01, Q9NWP1
      UniProtKB/TrEMBL
      G3V5Z3
      Related
      ENSP00000450883.1, ENST00000554943.6
      Conserved Domains (3) summary
      pfam04802
      Location:166357
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:765
      PH-like; Pleckstrin homology-like domain
      cl26969
      Location:325402
      Vitellogenin_N; Lipoprotein amino terminal region

    RNA

    1. NR_158976.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL133153
    2. NR_169191.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL133153
    3. NR_169192.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL133153
    4. NR_169193.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL133153

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      91457508..91510554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431561.1XP_047287517.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X2

      UniProtKB/TrEMBL
      G3V5Z3
    2. XM_005267842.3XP_005267899.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1

      See identical proteins and their annotated locations for XP_005267899.1

      UniProtKB/Swiss-Prot
      Q69YK6, Q6IN85, Q86U23, Q86YI7, Q8IVG1, Q9H3F1, Q9H7U8, Q9NV01, Q9NWP1
      UniProtKB/TrEMBL
      G3V5Z3
      Conserved Domains (3) summary
      pfam04802
      Location:166357
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:765
      PH-like; Pleckstrin homology-like domain
      cl26969
      Location:325402
      Vitellogenin_N; Lipoprotein amino terminal region
    3. XM_047431563.1XP_047287519.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X4

      UniProtKB/TrEMBL
      H0YIY8
      Related
      ENSP00000450473.1, ENST00000554308.5
    4. XM_047431562.1XP_047287518.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X3

      UniProtKB/TrEMBL
      H0YIY8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      85682749..85735802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376345.1XP_054232320.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X2

      UniProtKB/TrEMBL
      G3V5Z3
    2. XM_054376344.1XP_054232319.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1

      UniProtKB/Swiss-Prot
      Q69YK6, Q6IN85, Q86U23, Q86YI7, Q8IVG1, Q9H3F1, Q9H7U8, Q9NV01, Q9NWP1
      UniProtKB/TrEMBL
      G3V5Z3
    3. XM_054376347.1XP_054232322.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X4

      UniProtKB/TrEMBL
      H0YIY8
    4. XM_054376346.1XP_054232321.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X3

      UniProtKB/TrEMBL
      H0YIY8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_017936.3: Suppressed sequence

      Description
      NM_017936.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    2. NM_032560.4: Suppressed sequence

      Description
      NM_032560.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.