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    ZNF446 zinc finger protein 446 [ Homo sapiens (human) ]

    Gene ID: 55663, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZNF446provided by HGNC
    Official Full Name
    zinc finger protein 446provided by HGNC
    Primary source
    HGNC:HGNC:21036
    See related
    Ensembl:ENSG00000083838 AllianceGenome:HGNC:21036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZSCAN30; ZSCAN52; ZKSCAN20
    Summary
    Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 4.7), ovary (RPKM 4.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZNF446 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58476352..58489533)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61572319..61585623)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58987719..59000900)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 324B Neighboring gene zinc finger protein 250 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr19:58962695-58963021 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11083 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58978178-58978794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58978795-58979409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15199 Neighboring gene zinc finger protein 324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15201 Neighboring gene Sharpr-MPRA regulatory region 9894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15203 Neighboring gene uncharacterized LOC112268251 Neighboring gene RNA, U6 small nuclear 1337, pseudogene Neighboring gene Sharpr-MPRA regulatory region 4347 Neighboring gene RNA, 7SL, cytoplasmic 693, pseudogene Neighboring gene uncharacterized LOC105372485 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15206 Neighboring gene solute carrier family 27 member 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:59017967-59018180

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    zinc finger protein 446
    Names
    zinc finger protein with KRAB and SCAN domains 20

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304453.1NP_001291382.1  zinc finger protein 446 isoform 2

      See identical proteins and their annotated locations for NP_001291382.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a shorter 5' UTR and differs in the 3' exon structure, compared to variant 1. The encoded isoform (2) has a distinct, shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AL833955, BQ441187, DA162028
      UniProtKB/TrEMBL
      Q8NDK2
      Conserved Domains (3) summary
      smart00431
      Location:22137
      SCAN; leucine rich region
      pfam01352
      Location:209237
      KRAB; KRAB box
      pfam02023
      Location:22110
      SCAN; SCAN domain
    2. NM_017908.4NP_060378.1  zinc finger protein 446 isoform 1

      See identical proteins and their annotated locations for NP_060378.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK000633, AL122108, DA162028
      Consensus CDS
      CCDS12982.1
      UniProtKB/Swiss-Prot
      Q96AF5, Q9NWS9
      UniProtKB/TrEMBL
      M0R202
      Related
      ENSP00000472802.1, ENST00000594369.6
      Conserved Domains (3) summary
      sd00017
      Location:334354
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:209238
      KRAB; KRAB box
      cl02605
      Location:22137
      SCAN; SCAN oligomerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      58476352..58489533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      61572319..61585623
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)