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    ZNF692 zinc finger protein 692 [ Homo sapiens (human) ]

    Gene ID: 55657, updated on 6-Jun-2024

    Summary

    Official Symbol
    ZNF692provided by HGNC
    Official Full Name
    zinc finger protein 692provided by HGNC
    Primary source
    HGNC:HGNC:26049
    See related
    Ensembl:ENSG00000171163 MIM:617758; AllianceGenome:HGNC:26049
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AREBP; Zfp692
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and regulation of gluconeogenesis. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 9.4), prostate (RPKM 7.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF692 in Genome Data Viewer
    Location:
    1q44
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (248850008..248859085, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (248288491..248297596, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (249144207..249153284, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:249120460-249121010 Neighboring gene microRNA 3124 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:249132357-249132858 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:249132859-249133358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2881 Neighboring gene zinc finger protein 672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2886 Neighboring gene ZNF692 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2887 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:249166437-249167278 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:249167279-249168120 Neighboring gene tRNA-Leu (anticodon CAA) 4-1 Neighboring gene piggyBac transposable element derived 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    zinc finger protein 692
    Names
    AICAR responsive element binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136036.3NP_001129508.1  zinc finger protein 692 isoform 1

      See identical proteins and their annotated locations for NP_001129508.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK302187, AL672291, DA147512, DB520788, H07076
      Consensus CDS
      CCDS44348.1
      UniProtKB/Swiss-Prot
      Q9BU19
      Related
      ENSP00000391200.1, ENST00000451251.5
      Conserved Domains (4) summary
      COG5048
      Location:389490
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:366388
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:394416
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:408433
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001193328.2NP_001180257.1  zinc finger protein 692 isoform 3

      See identical proteins and their annotated locations for NP_001180257.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains a different first exon, which results in the use of a downstream start codon, and lacks an alternate exon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK225535, AK302187, H07076
      Consensus CDS
      CCDS53487.1
      UniProtKB/Swiss-Prot
      Q9BU19
      Related
      ENSP00000355427.3, ENST00000366471.7
      Conserved Domains (3) summary
      sd00017
      Location:316338
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:344366
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:358383
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001350072.2NP_001337001.1  zinc finger protein 692 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains a different first exon, which results in the use of a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting protein (isoform 4) has a shorter N-terminus and lacks an internal aa when it is compared to isoform 1.
      Source sequence(s)
      BC002948, DA319079
      Conserved Domains (4) summary
      COG5189
      Location:289407
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5236
      Location:357484
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:360382
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl26386
      Location:208332
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    4. NM_001350073.2NP_001337002.1  zinc finger protein 692 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains a different first exon, and uses alternate splice sites at another exon in the 5' region, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 5) has a shorter N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AL672291, BC002948, DA319079, DA765600
      UniProtKB/TrEMBL
      H0YCH4
      Conserved Domains (4) summary
      COG5189
      Location:86204
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5236
      Location:154281
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:157179
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl25580
      Location:4121
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
    5. NM_017865.4NP_060335.2  zinc finger protein 692 isoform 2

      See identical proteins and their annotated locations for NP_060335.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different first exon, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
      Source sequence(s)
      BC002948, DA319079
      Consensus CDS
      CCDS31127.1
      UniProtKB/Swiss-Prot
      B4DXZ0, Q5SRA5, Q5SRA6, Q9BU19, Q9HBC9, Q9NW93, Q9NWY6, Q9UF97
      Related
      ENSP00000305483.5, ENST00000306601.9
      Conserved Domains (4) summary
      COG5189
      Location:290408
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5236
      Location:358485
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:361383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl25580
      Location:208325
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      248850008..248859085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424581.1XP_047280537.1  zinc finger protein 692 isoform X7

    2. XM_017001698.2XP_016857187.1  zinc finger protein 692 isoform X4

      Conserved Domains (4) summary
      COG5189
      Location:289407
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5236
      Location:357484
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:360382
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl26386
      Location:208332
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    3. XM_017001700.2XP_016857189.1  zinc finger protein 692 isoform X6

    4. XM_011544222.2XP_011542524.1  zinc finger protein 692 isoform X3

      See identical proteins and their annotated locations for XP_011542524.1

      UniProtKB/Swiss-Prot
      B4DXZ0, Q5SRA5, Q5SRA6, Q9BU19, Q9HBC9, Q9NW93, Q9NWY6, Q9UF97
      Conserved Domains (4) summary
      COG5189
      Location:290408
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5236
      Location:358485
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:361383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl25580
      Location:208325
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
    5. XM_011544221.3XP_011542523.2  zinc finger protein 692 isoform X2

      UniProtKB/TrEMBL
      H0YCH4
      Conserved Domains (5) summary
      COG5048
      Location:179280
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:156178
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:198223
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:124202
      zf-C2H2_8; C2H2-type zinc ribbon
      cl25580
      Location:4120
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
    6. XM_017001699.3XP_016857188.2  zinc finger protein 692 isoform X5

      UniProtKB/TrEMBL
      H0YCH4
      Related
      ENSP00000431582.1, ENST00000476503.5
      Conserved Domains (3) summary
      COG5189
      Location:62178
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5236
      Location:128255
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:131153
      ZF_C2H2; C2H2 Zn finger [structural motif]
    7. XM_011544220.3XP_011542522.2  zinc finger protein 692 isoform X1

      UniProtKB/TrEMBL
      H0YCH4
      Conserved Domains (4) summary
      COG5189
      Location:86204
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5236
      Location:154281
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:157179
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl25580
      Location:4121
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
    8. XM_047424596.1XP_047280552.1  zinc finger protein 692 isoform X10

    9. XM_017001702.3XP_016857191.1  zinc finger protein 692 isoform X6

    10. XM_047424586.1XP_047280542.1  zinc finger protein 692 isoform X9

    11. XM_047424599.1XP_047280555.1  zinc finger protein 692 isoform X1

      UniProtKB/TrEMBL
      H0YCH4
    12. XM_024448274.2XP_024304042.1  zinc finger protein 692 isoform X1

      UniProtKB/TrEMBL
      H0YCH4
      Conserved Domains (4) summary
      COG5189
      Location:86204
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      COG5236
      Location:154281
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:157179
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl25580
      Location:4121
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
    13. XM_011544227.2XP_011542529.1  zinc finger protein 692 isoform X9

      See identical proteins and their annotated locations for XP_011542529.1

      Conserved Domains (4) summary
      COG5048
      Location:357458
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:334356
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:362384
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:376401
      zf-H2C2_2; Zinc-finger double domain
    14. XM_047424603.1XP_047280559.1  zinc finger protein 692 isoform X1

      UniProtKB/TrEMBL
      H0YCH4
      Related
      ENST00000533927.5
    15. XM_047424583.1XP_047280539.1  zinc finger protein 692 isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      248288491..248297596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337551.1XP_054193526.1  zinc finger protein 692 isoform X7

    2. XM_054337548.1XP_054193523.1  zinc finger protein 692 isoform X4

    3. XM_054337550.1XP_054193525.1  zinc finger protein 692 isoform X6

    4. XM_054337547.1XP_054193522.1  zinc finger protein 692 isoform X3

      UniProtKB/Swiss-Prot
      B4DXZ0, Q5SRA5, Q5SRA6, Q9BU19, Q9HBC9, Q9NW93, Q9NWY6, Q9UF97
    5. XM_054337546.1XP_054193521.1  zinc finger protein 692 isoform X2

      UniProtKB/TrEMBL
      H0YCH4
    6. XM_054337549.1XP_054193524.1  zinc finger protein 692 isoform X5

      UniProtKB/TrEMBL
      H0YCH4
    7. XM_054337545.1XP_054193520.1  zinc finger protein 692 isoform X1

      UniProtKB/TrEMBL
      H0YCH4
    8. XM_054337555.1XP_054193530.1  zinc finger protein 692 isoform X10

    9. XM_054337553.1XP_054193528.1  zinc finger protein 692 isoform X6

    10. XM_054337557.1XP_054193532.1  zinc finger protein 692 isoform X1

      UniProtKB/TrEMBL
      H0YCH4
    11. XM_054337556.1XP_054193531.1  zinc finger protein 692 isoform X1

      UniProtKB/TrEMBL
      H0YCH4
    12. XM_054337554.1XP_054193529.1  zinc finger protein 692 isoform X9

    13. XM_054337558.1XP_054193533.1  zinc finger protein 692 isoform X1

      UniProtKB/TrEMBL
      H0YCH4
    14. XM_054337552.1XP_054193527.1  zinc finger protein 692 isoform X8