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    NHP2 NHP2 ribonucleoprotein [ Homo sapiens (human) ]

    Gene ID: 55651, updated on 11-Jul-2021

    Summary

    Official Symbol
    NHP2provided by HGNC
    Official Full Name
    NHP2 ribonucleoproteinprovided by HGNC
    Primary source
    HGNC:HGNC:14377
    See related
    Ensembl:ENSG00000145912 MIM:606470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DKCB2; NHP2P; NOLA2
    Summary
    This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
    Expression
    Ubiquitous expression in esophagus (RPKM 36.2), brain (RPKM 32.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See NHP2 in Genome Data Viewer
    Location:
    5q35.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (178149463..178153885, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (177576464..177580886, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377754 Neighboring gene NEDD4 binding protein 3 Neighboring gene required for meiotic nuclear division 5 homolog B Neighboring gene NAD(P)HX epimerase pseudogene Neighboring gene germ cell-less 2, spermatogenesis associated

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human NHP2 ribonucleoprotein homolog (yeast) (NHP2) at amino acid residues 27-28 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables box H/ACA snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables box H/ACA snoRNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables telomerase RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    H/ACA ribonucleoprotein complex subunit 2
    Names
    NHP2 ribonucleoprotein homolog
    NHP2-like protein
    nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs)
    snoRNP protein NHP2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011765.1 RefSeqGene

      Range
      5001..9498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_346

    mRNA and Protein(s)

    1. NM_001034833.2NP_001030005.1  H/ACA ribonucleoprotein complex subunit 2 isoform b

      See identical proteins and their annotated locations for NP_001030005.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting protein (isoform b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AJ293309, BG827491, BM913344
      Consensus CDS
      CCDS34308.1
      UniProtKB/Swiss-Prot
      Q9NX24
      UniProtKB/TrEMBL
      J3QSY4
      Related
      ENSP00000366276.2, ENST00000314397.8
      Conserved Domains (1) summary
      cd21104
      Location:3274
      SNU13; U4/U6.U5 small nuclear ribonucleoprotein SNU13
    2. NM_017838.4NP_060308.1  H/ACA ribonucleoprotein complex subunit 2 isoform a

      See identical proteins and their annotated locations for NP_060308.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).
      Source sequence(s)
      AJ293309, BC000009, BE797477
      Consensus CDS
      CCDS4432.1
      UniProtKB/Swiss-Prot
      Q9NX24
      Related
      ENSP00000274606.4, ENST00000274606.8
      Conserved Domains (1) summary
      cd21104
      Location:32130
      SNU13; U4/U6.U5 small nuclear ribonucleoprotein SNU13

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      178149463..178153885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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