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    PNRC2 proline rich nuclear receptor coactivator 2 [ Homo sapiens (human) ]

    Gene ID: 55629, updated on 5-Mar-2024

    Summary

    Official Symbol
    PNRC2provided by HGNC
    Official Full Name
    proline rich nuclear receptor coactivator 2provided by HGNC
    Primary source
    HGNC:HGNC:23158
    See related
    Ensembl:ENSG00000189266 MIM:611882; AllianceGenome:HGNC:23158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in Golgi apparatus; P-body; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Note: GeneID 100132235 was merged into this record because the clone on which it was annotated, BX511012.5, was determined to be redundent. [27 May 2009]
    Expression
    Ubiquitous expression in thyroid (RPKM 68.8), lymph node (RPKM 67.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    1p36.11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (23959164..23963462)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (23797250..23800884)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24286318..24289952)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microRNA 378f Neighboring gene uncharacterized LOC124903877 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:24275932-24276152 Neighboring gene H3 histone pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24284548-24285176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 386 Neighboring gene serine and arginine rich splicing factor 10 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24306044-24307034 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24307035-24308025 Neighboring gene uncharacterized LOC105378615

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20312, MGC99541

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    proline-rich nuclear receptor coactivator 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017761.4NP_060231.1  proline-rich nuclear receptor coactivator 2

      See identical proteins and their annotated locations for NP_060231.1

      Status: VALIDATED

      Source sequence(s)
      AK311305, BC001959, BC078177, DA043474
      Consensus CDS
      CCDS246.1
      UniProtKB/Swiss-Prot
      B4DU72, Q9NPJ4
      Related
      ENSP00000334840.7, ENST00000334351.8
      Conserved Domains (1) summary
      pfam15365
      Location:91137
      PNRC; Proline-rich nuclear receptor coactivator

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      23959164..23963462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001691.1XP_016857180.1  proline-rich nuclear receptor coactivator 2 isoform X1

      UniProtKB/Swiss-Prot
      B4DU72, Q9NPJ4
      Related
      ENSP00000497590.1, ENST00000647887.1
      Conserved Domains (1) summary
      pfam15365
      Location:91137
      PNRC; Proline-rich nuclear receptor coactivator

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      23797250..23800884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)