U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    MED29 mediator complex subunit 29 [ Homo sapiens (human) ]

    Gene ID: 55588, updated on 17-Jun-2024

    Summary

    Official Symbol
    MED29provided by HGNC
    Official Full Name
    mediator complex subunit 29provided by HGNC
    Primary source
    HGNC:HGNC:23074
    See related
    Ensembl:ENSG00000063322 MIM:612914; AllianceGenome:HGNC:23074
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IXL; MED2
    Summary
    MED29 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et al., 2003 [PubMed 14576168]).[supplied by OMIM, Aug 2009]
    Expression
    Ubiquitous expression in brain (RPKM 2.7), thyroid (RPKM 2.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MED29 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39391378..39400641)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42195658..42204924)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39882018..39891281)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 4B Neighboring gene RNA, 7SL, cytoplasmic 566, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr19:39880404-39880535 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14613 Neighboring gene PAF1 homolog, Paf1/RNA polymerase II complex component Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14614 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14615 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39893943-39894450 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39897901-39898538 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39898539-39899177 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39899178-39899815 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:39900078-39900668 Neighboring gene microRNA 4530 Neighboring gene ZFP36 ring finger protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp434H247

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of core mediator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 29
    Names
    intersex-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317770.3NP_001304699.2  mediator of RNA polymerase II transcription subunit 29 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice acceptor site in the 3' coding region, which results in a frame-shift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC011500, AK124629, AK298014, AY729650, BQ271530
      Consensus CDS
      CCDS92614.1
      UniProtKB/TrEMBL
      M0R3F3
      Related
      ENSP00000472501.2, ENST00000594368.5
      Conserved Domains (1) summary
      pfam11568
      Location:53120
      Med29; Mediator complex subunit 29
    2. NM_017592.4NP_060062.2  mediator of RNA polymerase II transcription subunit 29 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC011500, AK124629, AY729650, BQ271530
      Consensus CDS
      CCDS33021.2
      UniProtKB/Swiss-Prot
      B4DNQ6, M0R2E4, Q5XX09, Q9NTF4, Q9NX70
      UniProtKB/TrEMBL
      B4DN56
      Related
      ENSP00000314343.5, ENST00000315588.11
      Conserved Domains (1) summary
      pfam11568
      Location:53187
      Med29; Mediator complex subunit 29

    RNA

    1. NR_133915.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC011500, AK090877, AY729650, BQ271530

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      39391378..39400641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      42195658..42204924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)