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    CNOT11 CCR4-NOT transcription complex subunit 11 [ Homo sapiens (human) ]

    Gene ID: 55571, updated on 5-Mar-2024

    Summary

    Official Symbol
    CNOT11provided by HGNC
    Official Full Name
    CCR4-NOT transcription complex subunit 11provided by HGNC
    Primary source
    HGNC:HGNC:25217
    See related
    Ensembl:ENSG00000158435 MIM:620509; AllianceGenome:HGNC:25217
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C40; C2orf29
    Summary
    Predicted to be involved in mRNA catabolic process and negative regulation of translation. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 19.6), placenta (RPKM 16.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See CNOT11 in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (101252886..101270316)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (101711589..101729019)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101869348..101886778)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:101768548-101769048 Neighboring gene TBC1D8 antisense RNA 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:101775410-101776609 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:101779352-101779869 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:101866397-101866896 Neighboring gene uncharacterized LOC124906053 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:101869253-101870165 Neighboring gene uncharacterized LOC105373511 Neighboring gene small nucleolar RNA, C/D box 89 Neighboring gene ring finger protein 149 Neighboring gene uncharacterized LOC124906052

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA poly(A) tail shortening NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of CCR4-NOT complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 11
    Names
    UPF0760 protein C2orf29

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017546.5NP_060016.3  CCR4-NOT transcription complex subunit 11

      See identical proteins and their annotated locations for NP_060016.3

      Status: VALIDATED

      Source sequence(s)
      BC018664, BM923954, BX394182
      Consensus CDS
      CCDS2050.1
      UniProtKB/Swiss-Prot
      Q6P2M9, Q8N681, Q9UKZ1
      Related
      ENSP00000289382.3, ENST00000289382.8
      Conserved Domains (1) summary
      pfam10155
      Location:371494
      DUF2363; Uncharacterized conserved protein (DUF2363)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      101252886..101270316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      101711589..101729019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)