U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 [ Homo sapiens (human) ]

    Gene ID: 55529, updated on 5-Mar-2024

    Summary

    Official Symbol
    PIP4P2provided by HGNC
    Official Full Name
    phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2provided by HGNC
    Primary source
    HGNC:HGNC:25452
    See related
    Ensembl:ENSG00000155099 MIM:609864; AllianceGenome:HGNC:25452
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TMEM55A
    Summary
    TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 11.6), adrenal (RPKM 9.7) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    8q21.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (90993802..91040859, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (92118724..92165782, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (92006030..92053087, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375635 Neighboring gene N-terminal EF-hand calcium binding protein 1 Neighboring gene uncharacterized LOC105375634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19353 Neighboring gene chromosome 8 open reading frame 88 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19354 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19355 Neighboring gene OTUD6B antisense RNA 1 (head to head) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27614 Neighboring gene OTU deubiquitinase 6B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp762O076

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in phagocytic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in phagocytic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
    Names
    PtdIns-4,5-P(2) 4-phosphatase type II
    ptdIns-4,5-P2 4-Ptase II
    transmembrane protein 55A
    type 2 PtdIns-4,5-P2 4-Ptase
    type II PtdIns-4,5-P(2) 4-phosphatase
    type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase
    NP_061180.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018710.3NP_061180.1  type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

      See identical proteins and their annotated locations for NP_061180.1

      Status: VALIDATED

      Source sequence(s)
      AC087439, AK313783, CR749733
      Consensus CDS
      CCDS6252.1
      UniProtKB/Swiss-Prot
      B2R9H4, Q68CU2, Q8N4L2
      UniProtKB/TrEMBL
      E5RFT4
      Related
      ENSP00000285419.3, ENST00000285419.8
      Conserved Domains (1) summary
      pfam09788
      Location:7250
      Tmemb_55A; Transmembrane protein 55A

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      90993802..91040859 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      92118724..92165782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)