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    PRCP prolylcarboxypeptidase [ Homo sapiens (human) ]

    Gene ID: 5547, updated on 3-Apr-2024

    Summary

    Official Symbol
    PRCPprovided by HGNC
    Official Full Name
    prolylcarboxypeptidaseprovided by HGNC
    Primary source
    HGNC:HGNC:9344
    See related
    Ensembl:ENSG00000137509 MIM:176785; AllianceGenome:HGNC:9344
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCP; HUMPCP
    Summary
    This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
    Expression
    Ubiquitous expression in placenta (RPKM 42.6), urinary bladder (RPKM 37.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PRCP in Genome Data Viewer
    Location:
    11q14.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (82822936..82901644, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (82759396..82838151, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (82533978..82612686, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 181 member B Neighboring gene long intergenic non-protein coding RNA 2734 Neighboring gene RBMX pseudogene 3 Neighboring gene small nucleolar RNA U13 Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 6 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:82569102-82570301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5333 Neighboring gene MIR3 retrotransposon enhancer-blocking element Neighboring gene uncharacterized LOC124902602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3817 Neighboring gene DNA damage induced apoptosis suppressor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3818 Neighboring gene ribosomal protein L7a pseudogene 54

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC2202

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in angiogenesis involved in wound healing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in energy homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of systemic arterial blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in plasma kallikrein-kinin cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of blood vessel endothelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of thyroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    lysosomal Pro-X carboxypeptidase
    Names
    angiotensinase C
    lysosomal carboxypeptidase C
    proline carboxypeptidase
    NP_001306143.1
    NP_005031.1
    NP_955450.2
    XP_005274150.1
    XP_054225298.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001319214.2NP_001306143.1  lysosomal Pro-X carboxypeptidase isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus and lacks a predicted signal peptide compared to isoform 1.
      Source sequence(s)
      AA477618, AK302386, AP001646, AW627417, BC001500, BE154586, CB154314
      Consensus CDS
      CCDS91553.1
      UniProtKB/TrEMBL
      B7Z7Q6, E9PIG4, E9PNF7, E9PR42
      Related
      ENSP00000436095.2, ENST00000534264.2
      Conserved Domains (1) summary
      cl21494
      Location:1372
      Abhydrolase; alpha/beta hydrolases
    2. NM_005040.4NP_005031.1  lysosomal Pro-X carboxypeptidase isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_005031.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AA477618, AP001646, AW627417, BC001500, BE154586, BI827978, CB154314
      Consensus CDS
      CCDS8262.1
      UniProtKB/Swiss-Prot
      A8MU24, B2R7B7, B3KRK5, B5BU34, P42785
      UniProtKB/TrEMBL
      E9PNF7
      Related
      ENSP00000317362.3, ENST00000313010.8
      Conserved Domains (2) summary
      COG0596
      Location:104214
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cl21494
      Location:55477
      Abhydrolase; alpha/beta hydrolases
    3. NM_199418.4NP_955450.2  lysosomal Pro-X carboxypeptidase isoform 2 precursor

      See identical proteins and their annotated locations for NP_955450.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is longer than isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.
      Source sequence(s)
      AA477618, AK091786, AP001646, AW627417, BC001500, BE154586, CB154314
      Consensus CDS
      CCDS41695.1
      UniProtKB/TrEMBL
      E9PNF7
      Related
      ENSP00000377055.2, ENST00000393399.6
      Conserved Domains (2) summary
      COG0596
      Location:125235
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cl21494
      Location:78498
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      82822936..82901644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005274093.2XP_005274150.1  lysosomal Pro-X carboxypeptidase isoform X1

      See identical proteins and their annotated locations for XP_005274150.1

      UniProtKB/TrEMBL
      B7Z7Q6, E9PIG4, E9PNF7, E9PR42
      Related
      ENSP00000505064.1, ENST00000680566.1
      Conserved Domains (1) summary
      cl21494
      Location:1372
      Abhydrolase; alpha/beta hydrolases

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      82759396..82838151 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369323.1XP_054225298.1  lysosomal Pro-X carboxypeptidase isoform X1

      UniProtKB/TrEMBL
      B7Z7Q6, E9PIG4, E9PR42