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    CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 [ Homo sapiens (human) ]

    Gene ID: 55450, updated on 5-Mar-2024

    Summary

    Official Symbol
    CAMK2N1provided by HGNC
    Official Full Name
    calcium/calmodulin dependent protein kinase II inhibitor 1provided by HGNC
    Primary source
    HGNC:HGNC:24190
    See related
    Ensembl:ENSG00000162545 MIM:614986; AllianceGenome:HGNC:24190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRO1489
    Summary
    Enables calcium-dependent protein kinase inhibitor activity and protein kinase binding activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; negative regulation of cell population proliferation; and negative regulation of cellular protein metabolic process. Predicted to be located in synapse. Implicated in ovarian cancer; ovarian carcinoma; and prostate adenocarcinoma. Biomarker of hepatocellular carcinoma; oral squamous cell carcinoma; prostate cancer; and thyroid gland papillary carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in brain (RPKM 113.3), colon (RPKM 48.8) and 15 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    1p36.12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (20482391..20486210, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (20307345..20311164, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20808884..20812703, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20701977-20702476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 320 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:20706555-20707754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20727039-20727539 Neighboring gene NANOG hESC enhancer GRCh37_chr1:20729171-20729710 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:20732635-20733223 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:20737119-20737312 Neighboring gene MPRA-validated peak103 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 364 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:20769432-20769932 Neighboring gene uncharacterized LOC124903871 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20810004-20810938 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:20822193-20823392 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:20833973-20834972 Neighboring gene mitochondrial E3 ubiquitin protein ligase 1 Neighboring gene ribosomal protein S4X pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC22256

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium-dependent protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in long-term memory ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    calcium/calmodulin-dependent protein kinase II inhibitor 1
    Names
    CaMKIINalpha
    caMKII inhibitory protein alpha
    caMKIIN-alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018584.6NP_061054.2  calcium/calmodulin-dependent protein kinase II inhibitor 1

      See identical proteins and their annotated locations for NP_061054.2

      Status: VALIDATED

      Source sequence(s)
      AL391357, AY204901, BI820748, DB475389
      Consensus CDS
      CCDS207.1
      UniProtKB/Swiss-Prot
      Q7Z7J9
      Related
      ENSP00000364219.3, ENST00000375078.4
      Conserved Domains (1) summary
      pfam15170
      Location:178
      CaM-KIIN; Calcium/calmodulin-dependent protein kinase II inhibitor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      20482391..20486210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      20307345..20311164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)