U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    NPY4R neuropeptide Y receptor Y4 [ Homo sapiens (human) ]

    Gene ID: 5540, updated on 3-Apr-2024

    Summary

    Official Symbol
    NPY4Rprovided by HGNC
    Official Full Name
    neuropeptide Y receptor Y4provided by HGNC
    Primary source
    HGNC:HGNC:9329
    See related
    Ensembl:ENSG00000204174 MIM:601790; AllianceGenome:HGNC:9329
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Y4; PP1; PPYR1; NPY4-R
    Summary
    Enables pancreatic polypeptide receptor activity and peptide hormone binding activity. Involved in G protein-coupled receptor signaling pathway. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon (RPKM 2.9), skin (RPKM 1.7) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    10q11.22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (46461099..46470668, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (47347139..47357909, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (47083457..47088320)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47752508-47753049 Neighboring gene annexin A8 like 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:47152525-47153140 Neighboring gene long intergenic non-protein coding RNA 842 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 33 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47124851-47125351 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47124350-47124850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:47107598-47108554 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47101901-47102401 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:47089605-47090205 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:47033702-47034570 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47034571-47035439 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47047925-47048424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:47057528-47058124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47021543-47022511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47013295-47013796 Neighboring gene uncharacterized LOC124902419 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:47008064-47008694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:46992923-46993628 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:46991512-46992217 Neighboring gene G protein regulated inducer of neurite outgrowth 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:46975535-46976296 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:46974774-46975534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:46974012-46974773 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:46969747-46970624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:46968867-46969746 Neighboring gene Sharpr-MPRA regulatory regions 2784 and 8617 duplicate 1 Neighboring gene SYT15 antisense RNA 1 Neighboring gene synaptotagmin 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC116897

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pancreatic polypeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pancreatic polypeptide receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide hormone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    neuropeptide Y receptor type 4
    Names
    pancreatic polypeptide receptor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278794.2NP_001265723.1  neuropeptide Y receptor type 4

      See identical proteins and their annotated locations for NP_001265723.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC244230
      Consensus CDS
      CCDS73100.1
      UniProtKB/Swiss-Prot
      P50391, Q13456, Q5ISU3, Q5T2X9, Q6FH06
      UniProtKB/TrEMBL
      Q4KKW2
      Related
      ENSP00000480883.1, ENST00000612632.3
      Conserved Domains (1) summary
      pfam00001
      Location:58322
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. NM_005972.6NP_005963.4  neuropeptide Y receptor type 4

      See identical proteins and their annotated locations for NP_005963.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC244230
      Consensus CDS
      CCDS73100.1
      UniProtKB/Swiss-Prot
      P50391, Q13456, Q5ISU3, Q5T2X9, Q6FH06
      UniProtKB/TrEMBL
      Q4KKW2
      Related
      ENSP00000363431.1, ENST00000374312.5
      Conserved Domains (1) summary
      pfam00001
      Location:58322
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      46461099..46470668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539937.4XP_011538239.1  neuropeptide Y receptor type 4 isoform X1

      See identical proteins and their annotated locations for XP_011538239.1

      UniProtKB/Swiss-Prot
      P50391, Q13456, Q5ISU3, Q5T2X9, Q6FH06
      UniProtKB/TrEMBL
      Q4KKW2
      Conserved Domains (1) summary
      pfam00001
      Location:58322
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. XM_017016387.3XP_016871876.1  neuropeptide Y receptor type 4 isoform X1

      UniProtKB/Swiss-Prot
      P50391, Q13456, Q5ISU3, Q5T2X9, Q6FH06
      UniProtKB/TrEMBL
      Q4KKW2
      Conserved Domains (1) summary
      pfam00001
      Location:58322
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    3. XM_011539936.4XP_011538238.1  neuropeptide Y receptor type 4 isoform X1

      See identical proteins and their annotated locations for XP_011538238.1

      UniProtKB/Swiss-Prot
      P50391, Q13456, Q5ISU3, Q5T2X9, Q6FH06
      UniProtKB/TrEMBL
      Q4KKW2
      Conserved Domains (1) summary
      pfam00001
      Location:58322
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    4. XM_017016386.3XP_016871875.1  neuropeptide Y receptor type 4 isoform X1

      UniProtKB/Swiss-Prot
      P50391, Q13456, Q5ISU3, Q5T2X9, Q6FH06
      UniProtKB/TrEMBL
      Q4KKW2
      Conserved Domains (1) summary
      pfam00001
      Location:58322
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RNA

    1. XR_007061972.1 RNA Sequence

    2. XR_001747124.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      47347139..47357909 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366238.1XP_054222213.1  neuropeptide Y receptor type 4 isoform X1

      UniProtKB/Swiss-Prot
      P50391, Q13456, Q5ISU3, Q5T2X9, Q6FH06
    2. XM_054366237.1XP_054222212.1  neuropeptide Y receptor type 4 isoform X1

      UniProtKB/Swiss-Prot
      P50391, Q13456, Q5ISU3, Q5T2X9, Q6FH06
    3. XM_054366236.1XP_054222211.1  neuropeptide Y receptor type 4 isoform X1

      UniProtKB/Swiss-Prot
      P50391, Q13456, Q5ISU3, Q5T2X9, Q6FH06

    RNA

    1. XR_007080979.1 RNA Sequence

    2. XR_007080978.1 RNA Sequence

    3. XR_007080980.1 RNA Sequence