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    PI4K2A phosphatidylinositol 4-kinase type 2 alpha [ Homo sapiens (human) ]

    Gene ID: 55361, updated on 2-May-2024

    Summary

    Official Symbol
    PI4K2Aprovided by HGNC
    Official Full Name
    phosphatidylinositol 4-kinase type 2 alphaprovided by HGNC
    Primary source
    HGNC:HGNC:30031
    See related
    Ensembl:ENSG00000155252 MIM:609763; AllianceGenome:HGNC:30031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NEDMSB; PI4KII; PIK42A
    Summary
    Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in placenta (RPKM 11.9), gall bladder (RPKM 10.1) and 25 other tissues See more
    Orthologs
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    Genomic context

    Location:
    10q24.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (97640671..97676434)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (98520873..98556635)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99400428..99436191)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10262 Neighboring gene chromosome 10 open reading frame 62 Neighboring gene 4-hydroxy-2-oxoglutarate aldolase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:99366549-99367050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:99367051-99367550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3853 Neighboring gene MORN repeat containing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3854 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:99399170-99399353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3856 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:99411103-99412302 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99435535-99436034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3857 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:99446822-99448021 Neighboring gene arginine vasopressin induced 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2685 Neighboring gene MARVEL domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Rab27a is required for plasma membrane delivery of PI4K2A and HIV-1 Gag assembly in Jurkat cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp761G1923

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol 4-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 1-phosphatidylinositol 4-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 1-phosphatidylinositol 4-kinase activity TAS
    Traceable Author Statement
    more info
     
    enables AP-3 adaptor complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylinositol biosynthetic process TAS
    Traceable Author Statement
    more info
     
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of BLOC-1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in growing cell tip ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lysosomal membrane HDA PubMed 
    located_in membrane HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol 4-kinase type 2-alpha
    Names
    phosphatidylinositol 4-kinase type II (PI4KII)
    phosphatidylinositol 4-kinase type II-alpha
    NP_060895.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018425.4NP_060895.1  phosphatidylinositol 4-kinase type 2-alpha

      See identical proteins and their annotated locations for NP_060895.1

      Status: VALIDATED

      Source sequence(s)
      AL355315
      Consensus CDS
      CCDS7469.1
      UniProtKB/Swiss-Prot
      D3DR59, Q9BTU6, Q9NSG8
      Related
      ENSP00000359665.3, ENST00000370631.4
      Conserved Domains (1) summary
      pfam00454
      Location:133429
      PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      97640671..97676434
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      98520873..98556635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)