U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    SHFL shiftless antiviral inhibitor of ribosomal frameshifting [ Homo sapiens (human) ]

    Gene ID: 55337, updated on 17-Jun-2024

    Summary

    Official Symbol
    SHFLprovided by HGNC
    Official Full Name
    shiftless antiviral inhibitor of ribosomal frameshiftingprovided by HGNC
    Primary source
    HGNC:HGNC:25649
    See related
    Ensembl:ENSG00000130813 MIM:616808; AllianceGenome:HGNC:25649
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SFL; IRAV; RyDEN; C19orf66
    Summary
    This gene is an interferon stimulated gene (ISG) that inhibits viral replication. The encoded protein binds nucleic acids and inhibits programmed -1 ribosomal frameshifting required for translation by many RNA viruses. Viruses inhibited by the protein include Zika virus, dengue virus and the coronaviruses, SARS-CoV and SARS-CoV2. [provided by RefSeq, Aug 2021]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Ubiquitous expression in liver (RPKM 17.9), spleen (RPKM 17.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SHFL in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10086317..10093243)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10212537..10219461)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10196993..10203919)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene microRNA 5589 Neighboring gene complement component 3 precursor pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10185500-10185601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10052 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10054 Neighboring gene angiopoietin like 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13937 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10216675-10217318 Neighboring gene PPAN-P2RY11 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10218607-10219250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10220162-10220743 Neighboring gene small nucleolar RNA, C/D box 105 Neighboring gene small nucleolar RNA, C/D box 105B Neighboring gene peter pan homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ11286, FLJ40743

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    shiftless antiviral inhibitor of ribosomal frameshifting protein
    Names
    Repressor of yield of Dengue virus
    UPF0515 protein C19orf66
    interferon-regulated antiviral protein
    repressor of yield of DENV protein
    shiftless

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308277.2NP_001295206.1  shiftless antiviral inhibitor of ribosomal frameshifting protein isoform 2

      See identical proteins and their annotated locations for NP_001295206.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      BC026180, BC035817, DB481173
      Consensus CDS
      CCDS77231.1
      UniProtKB/Swiss-Prot
      Q9NUL5
      Related
      ENSP00000467182.1, ENST00000591813.5
      Conserved Domains (1) summary
      pfam15135
      Location:16232
      UPF0515; Uncharacterized protein UPF0515
    2. NM_018381.4NP_060851.2  shiftless antiviral inhibitor of ribosomal frameshifting protein isoform 1

      See identical proteins and their annotated locations for NP_060851.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK002148, BC010847, DB481173
      Consensus CDS
      CCDS45957.1
      UniProtKB/Swiss-Prot
      A8MQT9, Q4G188, Q8IYH6, Q8N8V1, Q9NUL5
      Related
      ENSP00000253110.10, ENST00000253110.16
      Conserved Domains (1) summary
      pfam15135
      Location:16268
      UPF0515; Uncharacterized protein UPF0515

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      10086317..10093243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439048.1XP_047295004.1  shiftless antiviral inhibitor of ribosomal frameshifting protein isoform X3

    2. XM_011528122.2XP_011526424.1  shiftless antiviral inhibitor of ribosomal frameshifting protein isoform X4

      Conserved Domains (1) summary
      pfam15135
      Location:1678
      UPF0515; Uncharacterized protein UPF0515
    3. XM_047439046.1XP_047295002.1  shiftless antiviral inhibitor of ribosomal frameshifting protein isoform X1

    4. XM_047439047.1XP_047295003.1  shiftless antiviral inhibitor of ribosomal frameshifting protein isoform X2

      Related
      ENSP00000380978.3, ENST00000397881.7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      10212537..10219461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321378.1XP_054177353.1  shiftless antiviral inhibitor of ribosomal frameshifting protein isoform X3

    2. XM_054321379.1XP_054177354.1  shiftless antiviral inhibitor of ribosomal frameshifting protein isoform X4

    3. XM_054321376.1XP_054177351.1  shiftless antiviral inhibitor of ribosomal frameshifting protein isoform X1

    4. XM_054321377.1XP_054177352.1  shiftless antiviral inhibitor of ribosomal frameshifting protein isoform X2