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    OLAH oleoyl-ACP hydrolase [ Homo sapiens (human) ]

    Gene ID: 55301, updated on 11-Apr-2024

    Summary

    Official Symbol
    OLAHprovided by HGNC
    Official Full Name
    oleoyl-ACP hydrolaseprovided by HGNC
    Primary source
    HGNC:HGNC:25625
    See related
    Ensembl:ENSG00000152463 AllianceGenome:HGNC:25625
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TE2; SAST; AURA1; THEDC1
    Summary
    Enables dodecanoyl-[acyl-carrier-protein] hydrolase activity; myristoyl-[acyl-carrier-protein] hydrolase activity; and palmitoyl-[acyl-carrier-protein] hydrolase activity. Involved in medium-chain fatty acid biosynthetic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 8.6) and placenta (RPKM 2.3) See more
    Orthologs
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    Genomic context

    See OLAH in Genome Data Viewer
    Location:
    10p13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (15032195..15073853)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (15046189..15087828)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (15085942..15115852)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily E member 26 pseudogene Neighboring gene ACBD7-DCLRE1CP1 readthrough Neighboring gene olfactory receptor family 7 subfamily E member 115 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3088 Neighboring gene DNA cross-link repair 1C pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3089 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:15089045-15089853 Neighboring gene MPRA-validated peak869 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:15125454-15125977 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:15125978-15126500 Neighboring gene acyl-CoA binding domain containing 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2167 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 45

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ11106, MGC51852

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables fatty acyl-[ACP] hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in lipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in medium-chain fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    S-acyl fatty acid synthase thioesterase, medium chain
    Names
    augmented in rheumatoid arthritis 1
    oleoyl-acyl-carrier-protein hydrolase
    thioesterase 2
    thioesterase II
    thioesterase domain containing 1
    thioesterase domain-containing protein 1
    NP_001034791.1
    NP_060794.1
    XP_016871865.1
    XP_024303828.1
    XP_047281379.1
    XP_054222181.1
    XP_054222182.1
    XP_054222183.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039702.3NP_001034791.1  S-acyl fatty acid synthase thioesterase, medium chain isoform 2

      See identical proteins and their annotated locations for NP_001034791.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK001968, AL590365, BC050372, BG281536
      Consensus CDS
      CCDS31152.1
      UniProtKB/Swiss-Prot
      Q5VUB6, Q9NUW1, Q9NV23
      Related
      ENSP00000367473.4, ENST00000378228.8
      Conserved Domains (1) summary
      COG3208
      Location:22242
      GrsT; Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and catabolism]
    2. NM_018324.3NP_060794.1  S-acyl fatty acid synthase thioesterase, medium chain isoform 1

      See identical proteins and their annotated locations for NP_060794.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK001968, AL590365, BG281536, BI830605
      Consensus CDS
      CCDS7106.1
      UniProtKB/Swiss-Prot
      Q9NV23
      Related
      ENSP00000367462.3, ENST00000378217.3
      Conserved Domains (2) summary
      COG3208
      Location:22295
      GrsT; Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and catabolism]
      pfam12697
      Location:106297
      Abhydrolase_6; Alpha/beta hydrolase family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      15032195..15073853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425423.1XP_047281379.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X1

    2. XM_024448060.2XP_024303828.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X2

      UniProtKB/Swiss-Prot
      Q5VUB6, Q9NUW1, Q9NV23
      Conserved Domains (1) summary
      COG3208
      Location:22242
      GrsT; Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and catabolism]
    3. XM_017016376.3XP_016871865.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X1

      UniProtKB/Swiss-Prot
      Q9NV23
      Conserved Domains (2) summary
      COG3208
      Location:22295
      GrsT; Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and catabolism]
      pfam12697
      Location:106297
      Abhydrolase_6; Alpha/beta hydrolase family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      15046189..15087828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366207.1XP_054222182.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X1

    2. XM_054366208.1XP_054222183.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X2

      UniProtKB/Swiss-Prot
      Q5VUB6, Q9NUW1, Q9NV23
    3. XM_054366206.1XP_054222181.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X1