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    ACOXL acyl-CoA oxidase like [ Homo sapiens (human) ]

    Gene ID: 55289, updated on 27-Nov-2024

    Summary

    Official Symbol
    ACOXLprovided by HGNC
    Official Full Name
    acyl-CoA oxidase likeprovided by HGNC
    Primary source
    HGNC:HGNC:25621
    See related
    Ensembl:ENSG00000153093 AllianceGenome:HGNC:25621
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACOX4
    Summary
    Predicted to enable acyl-CoA oxidase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase and lipid homeostasis. Predicted to be located in peroxisomal matrix. Predicted to be active in peroxisome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ACOXL in Genome Data Viewer
    Location:
    2q13
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (110732573..111118548)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (111155418..111543674)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (111490150..111876125)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:111434896-111435816 Neighboring gene uncharacterized LOC105373554 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:111435817-111436737 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111445059-111446030 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111446031-111447002 Neighboring gene Sharpr-MPRA regulatory region 12654 Neighboring gene uncharacterized LOC124906064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16374 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:111510337-111510838 Neighboring gene NANOG hESC enhancer GRCh37_chr2:111529706-111530207 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:111553982-111554181 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:111556532-111557731 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111558229-111558834 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:111559681-111560360 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:111570488-111570988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111594132-111595120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16375 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111616831-111617348 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111623769-111624474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111624475-111625179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111626664-111627274 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111631628-111632251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111634418-111635282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111661014-111661514 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:111731587-111731774 Neighboring gene NANOG hESC enhancer GRCh37_chr2:111755936-111756510 Neighboring gene ribosomal protein L5 pseudogene 9 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:111789964-111791163 Neighboring gene uncharacterized LOC124907866 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16378 Neighboring gene Sharpr-MPRA regulatory region 7769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16380 Neighboring gene ACOXL antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16381 Neighboring gene Sharpr-MPRA regulatory region 8028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11866 Neighboring gene BCL2 like 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111923374-111923874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16384 Neighboring gene uncharacterized LOC124907868

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
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    EBI GWAS Catalog
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    EBI GWAS Catalog
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    EBI GWAS Catalog
    Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
    EBI GWAS Catalog
    Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
    EBI GWAS Catalog
    Seventy-five genetic loci influencing the human red blood cell.
    EBI GWAS Catalog
    The genetic architecture of economic and political preferences.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ11042

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables acyl-CoA oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in peroxisomal matrix TAS
    Traceable Author Statement
    more info
     
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    acyl-coenzyme A oxidase-like protein
    Names
    acyl-CoA oxidase-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142807.4NP_001136279.1  acyl-coenzyme A oxidase-like protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC023131, AC096591, AC096670, AC114776
      Consensus CDS
      CCDS46389.1
      UniProtKB/Swiss-Prot
      Q9NUZ1
      UniProtKB/TrEMBL
      B4DU63
      Related
      ENSP00000407761.1, ENST00000439055.6
      Conserved Domains (2) summary
      PLN02636
      Location:34545
      PLN02636; acyl-coenzyme A oxidase
      cl09933
      Location:2545
      ACAD; Acyl-CoA dehydrogenase
    2. NM_001365487.2NP_001352416.1  acyl-coenzyme A oxidase-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC096591, AK300513, BC022268, HY017683
      Consensus CDS
      CCDS92841.1
      Related
      ENSP00000343717.4, ENST00000340561.8
      Conserved Domains (1) summary
      cl09933
      Location:2261
      ACAD; Acyl-CoA dehydrogenase
    3. NM_001371254.1NP_001358183.1  acyl-coenzyme A oxidase-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC023131, AC096591, AC096670, AC114776
      Consensus CDS
      CCDS42730.1
      UniProtKB/Swiss-Prot
      A2RRB7, B7WPB3, B7WPP7, E9PB20, Q53R27, Q53R31, Q53SC6, Q8TCE7, Q9NUZ1
      Related
      ENSP00000374461.4, ENST00000389811.8
      Conserved Domains (1) summary
      cl09933
      Location:2544
      ACAD; Acyl-CoA dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      110732573..111118548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511404.4XP_011509706.1  acyl-coenzyme A oxidase-like protein isoform X1

      See identical proteins and their annotated locations for XP_011509706.1

      UniProtKB/TrEMBL
      A0A7I2V3X2
      Related
      ENSP00000503683.1, ENST00000676595.2
      Conserved Domains (2) summary
      PLN02636
      Location:34575
      PLN02636; acyl-coenzyme A oxidase
      cl09933
      Location:2575
      ACAD; Acyl-CoA dehydrogenase
    2. XM_011511414.4XP_011509716.1  acyl-coenzyme A oxidase-like protein isoform X6

      Conserved Domains (1) summary
      cl09933
      Location:2522
      ACAD; Acyl-CoA dehydrogenase
    3. XM_047444905.1XP_047300861.1  acyl-coenzyme A oxidase-like protein isoform X9

    4. XM_011511411.4XP_011509713.1  acyl-coenzyme A oxidase-like protein isoform X4

      Conserved Domains (1) summary
      cl09933
      Location:2536
      ACAD; Acyl-CoA dehydrogenase
    5. XM_047444903.1XP_047300859.1  acyl-coenzyme A oxidase-like protein isoform X8

    6. XM_011511432.4XP_011509734.1  acyl-coenzyme A oxidase-like protein isoform X1

      See identical proteins and their annotated locations for XP_011509734.1

      UniProtKB/TrEMBL
      A0A7I2V3X2
      Conserved Domains (2) summary
      PLN02636
      Location:34575
      PLN02636; acyl-coenzyme A oxidase
      cl09933
      Location:2575
      ACAD; Acyl-CoA dehydrogenase
    7. XM_047444904.1XP_047300860.1  acyl-coenzyme A oxidase-like protein isoform X8

    8. XM_011511413.2XP_011509715.1  acyl-coenzyme A oxidase-like protein isoform X5

      Conserved Domains (2) summary
      PLN02636
      Location:34535
      PLN02636; acyl-coenzyme A oxidase
      cl09933
      Location:2544
      ACAD; Acyl-CoA dehydrogenase
    9. XM_011511409.2XP_011509711.1  acyl-coenzyme A oxidase-like protein isoform X3

      Conserved Domains (2) summary
      PLN02636
      Location:34535
      PLN02636; acyl-coenzyme A oxidase
      cl09933
      Location:2546
      ACAD; Acyl-CoA dehydrogenase
    10. XM_011511422.2XP_011509724.1  acyl-coenzyme A oxidase-like protein isoform X11

      See identical proteins and their annotated locations for XP_011509724.1

      Conserved Domains (1) summary
      cl09933
      Location:2489
      ACAD; Acyl-CoA dehydrogenase
    11. XM_011511415.3XP_011509717.1  acyl-coenzyme A oxidase-like protein isoform X7

      Conserved Domains (2) summary
      PLN02636
      Location:34552
      PLN02636; acyl-coenzyme A oxidase
      cl09933
      Location:2544
      ACAD; Acyl-CoA dehydrogenase
    12. XM_011511421.3XP_011509723.1  acyl-coenzyme A oxidase-like protein isoform X11

      See identical proteins and their annotated locations for XP_011509723.1

      Conserved Domains (1) summary
      cl09933
      Location:2489
      ACAD; Acyl-CoA dehydrogenase
    13. XM_047444906.1XP_047300862.1  acyl-coenzyme A oxidase-like protein isoform X12

    14. XM_011511423.2XP_011509725.1  acyl-coenzyme A oxidase-like protein isoform X11

      See identical proteins and their annotated locations for XP_011509725.1

      Conserved Domains (1) summary
      cl09933
      Location:2489
      ACAD; Acyl-CoA dehydrogenase
    15. XM_011511419.3XP_011509721.1  acyl-coenzyme A oxidase-like protein isoform X10

      UniProtKB/Swiss-Prot
      Q9NUZ1
      Conserved Domains (2) summary
      PLN02636
      Location:34505
      PLN02636; acyl-coenzyme A oxidase
      cl09933
      Location:2514
      ACAD; Acyl-CoA dehydrogenase
    16. XM_047444907.1XP_047300863.1  acyl-coenzyme A oxidase-like protein isoform X16

    17. XM_011511427.3XP_011509729.1  acyl-coenzyme A oxidase-like protein isoform X13

      Conserved Domains (1) summary
      cl09933
      Location:2486
      ACAD; Acyl-CoA dehydrogenase
    18. XM_011511429.3XP_011509731.1  acyl-coenzyme A oxidase-like protein isoform X15

      Conserved Domains (1) summary
      cl09933
      Location:2396
      ACAD; Acyl-CoA dehydrogenase
    19. XM_011511428.4XP_011509730.1  acyl-coenzyme A oxidase-like protein isoform X14

      Conserved Domains (1) summary
      cl09933
      Location:2396
      ACAD; Acyl-CoA dehydrogenase
    20. XM_017004431.2XP_016859920.1  acyl-coenzyme A oxidase-like protein isoform X17

    21. XM_047444908.1XP_047300864.1  acyl-coenzyme A oxidase-like protein isoform X20

    22. XM_017004432.3XP_016859921.1  acyl-coenzyme A oxidase-like protein isoform X18

    23. XM_011511405.4XP_011509707.1  acyl-coenzyme A oxidase-like protein isoform X1

      See identical proteins and their annotated locations for XP_011509707.1

      UniProtKB/TrEMBL
      A0A7I2V3X2
      Conserved Domains (2) summary
      PLN02636
      Location:34575
      PLN02636; acyl-coenzyme A oxidase
      cl09933
      Location:2575
      ACAD; Acyl-CoA dehydrogenase
    24. XM_011511406.4XP_011509708.1  acyl-coenzyme A oxidase-like protein isoform X1

      See identical proteins and their annotated locations for XP_011509708.1

      UniProtKB/TrEMBL
      A0A7I2V3X2
      Conserved Domains (2) summary
      PLN02636
      Location:34575
      PLN02636; acyl-coenzyme A oxidase
      cl09933
      Location:2575
      ACAD; Acyl-CoA dehydrogenase
    25. XM_011511407.4XP_011509709.1  acyl-coenzyme A oxidase-like protein isoform X2

      Conserved Domains (2) summary
      PLN02636
      Location:30571
      PLN02636; acyl-coenzyme A oxidase
      cl09933
      Location:33571
      ACAD; Acyl-CoA dehydrogenase
    26. XM_017004433.3XP_016859922.1  acyl-coenzyme A oxidase-like protein isoform X19

    27. XM_017004434.3XP_016859923.1  acyl-coenzyme A oxidase-like protein isoform X21

      Conserved Domains (2) summary
      PLN02636
      Location:1288
      PLN02636; acyl-coenzyme A oxidase
      cl09933
      Location:1288
      ACAD; Acyl-CoA dehydrogenase
    28. XM_011511434.4XP_011509736.1  acyl-coenzyme A oxidase-like protein isoform X21

      Conserved Domains (2) summary
      PLN02636
      Location:1288
      PLN02636; acyl-coenzyme A oxidase
      cl09933
      Location:1288
      ACAD; Acyl-CoA dehydrogenase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      111155418..111543674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342808.1XP_054198783.1  acyl-coenzyme A oxidase-like protein isoform X8

    2. XM_054342798.1XP_054198773.1  acyl-coenzyme A oxidase-like protein isoform X1

    3. XM_054342804.1XP_054198779.1  acyl-coenzyme A oxidase-like protein isoform X5

    4. XM_054342802.1XP_054198777.1  acyl-coenzyme A oxidase-like protein isoform X3

    5. XM_054342797.1XP_054198772.1  acyl-coenzyme A oxidase-like protein isoform X1

    6. XM_054342805.1XP_054198780.1  acyl-coenzyme A oxidase-like protein isoform X6

    7. XM_054342809.1XP_054198784.1  acyl-coenzyme A oxidase-like protein isoform X9

    8. XM_054342803.1XP_054198778.1  acyl-coenzyme A oxidase-like protein isoform X4

    9. XM_054342807.1XP_054198782.1  acyl-coenzyme A oxidase-like protein isoform X8

    10. XM_054342811.1XP_054198786.1  acyl-coenzyme A oxidase-like protein isoform X11

    11. XM_054342806.1XP_054198781.1  acyl-coenzyme A oxidase-like protein isoform X7

    12. XM_054342812.1XP_054198787.1  acyl-coenzyme A oxidase-like protein isoform X11

    13. XM_054342814.1XP_054198789.1  acyl-coenzyme A oxidase-like protein isoform X12

    14. XM_054342813.1XP_054198788.1  acyl-coenzyme A oxidase-like protein isoform X11

    15. XM_054342810.1XP_054198785.1  acyl-coenzyme A oxidase-like protein isoform X10

    16. XM_054342818.1XP_054198793.1  acyl-coenzyme A oxidase-like protein isoform X16

    17. XM_054342815.1XP_054198790.1  acyl-coenzyme A oxidase-like protein isoform X13

    18. XM_054342817.1XP_054198792.1  acyl-coenzyme A oxidase-like protein isoform X15

    19. XM_054342816.1XP_054198791.1  acyl-coenzyme A oxidase-like protein isoform X14

    20. XM_054342819.1XP_054198794.1  acyl-coenzyme A oxidase-like protein isoform X17

    21. XM_054342822.1XP_054198797.1  acyl-coenzyme A oxidase-like protein isoform X20

    22. XM_054342820.1XP_054198795.1  acyl-coenzyme A oxidase-like protein isoform X18

    23. XM_054342799.1XP_054198774.1  acyl-coenzyme A oxidase-like protein isoform X1

    24. XM_054342800.1XP_054198775.1  acyl-coenzyme A oxidase-like protein isoform X1

    25. XM_054342801.1XP_054198776.1  acyl-coenzyme A oxidase-like protein isoform X2

    26. XM_054342821.1XP_054198796.1  acyl-coenzyme A oxidase-like protein isoform X19

    27. XM_054342823.1XP_054198798.1  acyl-coenzyme A oxidase-like protein isoform X22

    28. XM_054342824.1XP_054198799.1  acyl-coenzyme A oxidase-like protein isoform X21

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105516.2: Suppressed sequence

      Description
      NM_001105516.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_001142808.1: Suppressed sequence

      Description
      NM_001142808.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    3. NM_018308.1: Suppressed sequence

      Description
      NM_018308.1: This RefSeq was permanently suppressed because the CDS was partial.