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    ARL8B ARF like GTPase 8B [ Homo sapiens (human) ]

    Gene ID: 55207, updated on 2-Nov-2024

    Summary

    Official Symbol
    ARL8Bprovided by HGNC
    Official Full Name
    ARF like GTPase 8Bprovided by HGNC
    Primary source
    HGNC:HGNC:25564
    See related
    Ensembl:ENSG00000134108 MIM:616596; AllianceGenome:HGNC:25564
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Gie1; ARL10C
    Summary
    Enables G protein activity; guanyl ribonucleotide binding activity; and tubulin binding activity. Involved in several processes, including antigen processing and presentation following phagocytosis; cytosolic transport; and vesicle fusion. Located in cytolytic granule membrane; midbody; and spindle midzone. Is active in early endosome membrane and lysosomal membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 48.8), thyroid (RPKM 43.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ARL8B in Genome Data Viewer
    Location:
    3p26.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (5122292..5180911)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (5116223..5174843)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (5163977..5222596)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene UBTF like 8 (pseudogene) Neighboring gene CD24 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14023 Neighboring gene uncharacterized LOC124906212 Neighboring gene Sharpr-MPRA regulatory region 5688 Neighboring gene Sharpr-MPRA regulatory region 5493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19379 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14024 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19380 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19381 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19383 Neighboring gene ER degradation enhancing alpha-mannosidase like protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19384 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:5255069-5255570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:5264003-5264559 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:5264560-5265115 Neighboring gene NANOG hESC enhancer GRCh37_chr3:5274159-5274668 Neighboring gene microRNA 4790

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Expression of HIV-1 Tat upregulates the abundance of ADP-ribosylation factor-like 8B (ARL8B) in the nucleoli of Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10702

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GDP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables alpha-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables beta-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anterograde axonal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antigen processing and presentation following phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in antigen processing and presentation of polysaccharide antigen via MHC class II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in autophagosome-lysosome fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion regulated lysosome exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in early endosome to Golgi transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endosome to lysosome transport of low-density lipoprotein particle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in late endosome to lysosome transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in late endosome to lysosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lysosome localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lysosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phagosome-lysosome fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in plasma membrane repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in viral exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytolytic granule membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ADP-ribosylation factor-like protein 8B
    Names
    ADP ribosylation factor like GTPase 8B
    ADP-ribosylation factor-like 10C
    ADP-ribosylation factor-like 8B
    ADP-ribosylation factor-like protein 10C
    GTPase indispensable for equal segregation of chromosomes 1
    novel small G protein indispensable for equal chromosome segregation 1
    NP_060654.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018184.3NP_060654.1  ADP-ribosylation factor-like protein 8B

      See identical proteins and their annotated locations for NP_060654.1

      Status: VALIDATED

      Source sequence(s)
      AK001564, BC063125
      Consensus CDS
      CCDS2566.1
      UniProtKB/Swiss-Prot
      B4DI85, Q9NVJ2
      UniProtKB/TrEMBL
      B2R7U5
      Related
      ENSP00000256496.3, ENST00000256496.8
      Conserved Domains (1) summary
      cd04159
      Location:22180
      Arl10_like; Arf-like 9 (Arl9) and 10 (Arl10) GTPases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      5122292..5180911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      5116223..5174843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)