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    MAP1S microtubule associated protein 1S [ Homo sapiens (human) ]

    Gene ID: 55201, updated on 17-Jun-2024

    Summary

    Official Symbol
    MAP1Sprovided by HGNC
    Official Full Name
    microtubule associated protein 1Sprovided by HGNC
    Primary source
    HGNC:HGNC:15715
    See related
    Ensembl:ENSG00000130479 MIM:607573; AllianceGenome:HGNC:15715
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAP8; BPY2IP1; C19orf5; VCY2IP1; VCY2IP-1
    Summary
    Enables DNA binding activity and cytoskeletal protein binding activity. Involved in microtubule bundle formation; neuron projection morphogenesis; and regulation of chromatin disassembly. Located in several cellular components, including microtubule cytoskeleton; nuclear lumen; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 11.7), brain (RPKM 7.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MAP1S in Genome Data Viewer
    Location:
    19p13.11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (17719480..17734513)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (17853600..17868633)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17830289..17845322)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17709342-17709923 Neighboring gene ribosomal protein L21 pseudogene 130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17715726-17716630 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17716631-17717535 Neighboring gene unc-13 homolog A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17797343-17798304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17798305-17799265 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:17812168-17812395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17828319-17828820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14283 Neighboring gene uncharacterized LOC124904649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17849672-17850172 Neighboring gene Sharpr-MPRA regulatory region 7159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10359 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr19:17864444-17864964 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr19:17864965-17865484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14284 Neighboring gene MPRA-validated peak3395 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17877027-17877564 Neighboring gene FCH and mu domain containing endocytic adaptor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14285 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17905145-17905842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17905843-17906540 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of MAP1S by shRNA inhibits HIV-1 infectivity in human PBMCs PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag MAP1A and MAP1S proteins activate HIV-1 retrograde trafficking by tethering capsids to microtubules in primary human macrophages PubMed
    gag MAP1A and MAP1S depletion leads to an accumulation of HIV-1 CA labelling throughout the cytoplasm, suggesting an inability both to reach the nuclear membrane and to uncoat PubMed
    gag MAP1A and MAP1S proteins interact with HIV-1 CA cores in primary human macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10669, MGC133087

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables DNA nuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables beta-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in autophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in dendrite development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule anchoring at centrosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule bundle formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrion transport along microtubule TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in neuron projection morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation of microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
     
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of microtubule associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    microtubule-associated protein 1S
    Names
    BPY2-interacting protein 1
    MAP-1S
    VCY2-interacting protein 1
    microtubule-associated protein 8
    variable charge Y chromosome 2-interacting protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308363.2NP_001295292.1  microtubule-associated protein 1S isoform 2

      See identical proteins and their annotated locations for NP_001295292.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, which results in a different 5' UTR and use of an alternate start codon and novel 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AA905204, AK294936, DB097723, DC401920
      Consensus CDS
      CCDS77262.1
      UniProtKB/TrEMBL
      A8K940
      Related
      ENSP00000439243.1, ENST00000544059.2
      Conserved Domains (1) summary
      cl23716
      Location:232278
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    2. NM_018174.6NP_060644.4  microtubule-associated protein 1S isoform 1

      See identical proteins and their annotated locations for NP_060644.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AA905204, BC007253, BC067115, BG771546, DB081409
      Consensus CDS
      CCDS32954.1
      UniProtKB/Swiss-Prot
      B4DH53, Q27QB1, Q66K74, Q6NXF1, Q8N3L8, Q8N3W5, Q8NI88, Q96H94, Q96IT4, Q96SP8, Q9BRC6, Q9H928, Q9NVK7
      UniProtKB/TrEMBL
      A8K940
      Related
      ENSP00000325313.3, ENST00000324096.9
      Conserved Domains (1) summary
      cl23716
      Location:258304
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      17719480..17734513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      17853600..17868633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321358.1XP_054177333.1  microtubule-associated protein 1S isoform X1