U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    LOC551970 dual oxidase [ Apis mellifera (honey bee) ]

    Gene ID: 551970, updated on 10-May-2024

    Summary

    Gene symbol
    LOC551970
    Gene description
    dual oxidase
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Apis mellifera
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Anthophila; Apidae; Apis
    Also known as
    Duox; GB51481
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LOC551970 in Genome Data Viewer
    Location:
    chromosome: LG3
    Exon count:
    23
    Annotation release Status Assembly LG Location
    104 current Amel_HAv3.1 (GCF_003254395.2) LG3 NC_037640.1 (4547770..4562135)
    103 previous assembly Amel_4.5 (GCF_000002195.4) LG3 NC_007072.3 (3751189..3901903, complement)

    Linkage Group LG3 - NC_037640.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 kinase beta-1 Neighboring gene ras guanine nucleotide exchange factor P Neighboring gene uncharacterized LOC413858 Neighboring gene dual oxidase maturation factor 1 mol Neighboring gene uncharacterized LOC102653989 Neighboring gene geminin DNA replication inhibitor

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables superoxide-generating NAD(P)H oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of NADPH oxidase complex IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    dual oxidase
    Names
    predicted dual oxidase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Apis mellifera Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Amel_HAv3.1 Primary Assembly

    Genomic

    1. NC_037640.1 Reference Amel_HAv3.1 Primary Assembly

      Range
      4547770..4562135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_026439457.1XP_026295242.1  dual oxidase isoform X2

      UniProtKB/TrEMBL
      A0A7M7KZ75, A0A7M7L500, A0A8B8GTV9, A0A8B8GU98, A7E3M3
      Conserved Domains (5) summary
      cd06186
      Location:12361415
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd09820
      Location:41594
      dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
      cd00051
      Location:831892
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01794
      Location:10561189
      Ferric_reduct; Ferric reductase like transmembrane component
      cl25352
      Location:778936
      EFh_PEF; The penta-EF hand (PEF) family
    2. XM_026439460.1XP_026295245.1  dual oxidase isoform X2

      UniProtKB/TrEMBL
      A0A7M7KZ75, A0A7M7L500, A0A8B8GTV9, A0A8B8GU98, A7E3M3
      Conserved Domains (5) summary
      cd06186
      Location:12361415
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd09820
      Location:41594
      dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
      cd00051
      Location:831892
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01794
      Location:10561189
      Ferric_reduct; Ferric reductase like transmembrane component
      cl25352
      Location:778936
      EFh_PEF; The penta-EF hand (PEF) family
    3. XM_026439461.1XP_026295246.1  dual oxidase isoform X2

      UniProtKB/TrEMBL
      A0A7M7KZ75, A0A7M7L500, A0A8B8GTV9, A0A8B8GU98, A7E3M3
      Conserved Domains (5) summary
      cd06186
      Location:12361415
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd09820
      Location:41594
      dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
      cd00051
      Location:831892
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01794
      Location:10561189
      Ferric_reduct; Ferric reductase like transmembrane component
      cl25352
      Location:778936
      EFh_PEF; The penta-EF hand (PEF) family
    4. XM_026439463.1XP_026295248.1  dual oxidase isoform X3

      UniProtKB/TrEMBL
      A0A7M7GMA8, A0A7M7MG50, A0A8B6YUL9, A0A8B8GVH7, A7E3M3
      Conserved Domains (5) summary
      cd06186
      Location:11921371
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd09820
      Location:12550
      dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
      cd00051
      Location:787848
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01794
      Location:10121145
      Ferric_reduct; Ferric reductase like transmembrane component
      cl25352
      Location:734892
      EFh_PEF; The penta-EF hand (PEF) family
    5. XM_026439458.1XP_026295243.1  dual oxidase isoform X2

      UniProtKB/TrEMBL
      A0A7M7KZ75, A0A7M7L500, A0A8B8GTV9, A0A8B8GU98, A7E3M3
      Conserved Domains (5) summary
      cd06186
      Location:12361415
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd09820
      Location:41594
      dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
      cd00051
      Location:831892
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01794
      Location:10561189
      Ferric_reduct; Ferric reductase like transmembrane component
      cl25352
      Location:778936
      EFh_PEF; The penta-EF hand (PEF) family
    6. XM_026439456.1XP_026295241.1  dual oxidase isoform X1

      UniProtKB/TrEMBL
      A0A7M7KZ50, A0A8B8GTV4, A7E3M3
      Conserved Domains (5) summary
      cd06186
      Location:13441523
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd09820
      Location:149702
      dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
      cd00051
      Location:9391000
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01794
      Location:11641297
      Ferric_reduct; Ferric reductase like transmembrane component
      cl25352
      Location:8861044
      EFh_PEF; The penta-EF hand (PEF) family
    7. XM_006560492.3XP_006560555.2  dual oxidase isoform X3

      UniProtKB/TrEMBL
      A0A7M7GMA8, A0A7M7MG50, A0A8B6YUL9, A0A8B8GVH7, A7E3M3
      Conserved Domains (5) summary
      cd06186
      Location:11921371
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd09820
      Location:12550
      dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
      cd00051
      Location:787848
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01794
      Location:10121145
      Ferric_reduct; Ferric reductase like transmembrane component
      cl25352
      Location:734892
      EFh_PEF; The penta-EF hand (PEF) family
    8. XM_026439459.1XP_026295244.1  dual oxidase isoform X2

      UniProtKB/TrEMBL
      A0A7M7KZ75, A0A7M7L500, A0A8B8GTV9, A0A8B8GU98, A7E3M3
      Conserved Domains (5) summary
      cd06186
      Location:12361415
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd09820
      Location:41594
      dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
      cd00051
      Location:831892
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01794
      Location:10561189
      Ferric_reduct; Ferric reductase like transmembrane component
      cl25352
      Location:778936
      EFh_PEF; The penta-EF hand (PEF) family
    9. XM_026439462.1XP_026295247.1  dual oxidase isoform X2

      UniProtKB/TrEMBL
      A0A7M7KZ75, A0A7M7L500, A0A8B8GTV9, A0A8B8GU98, A7E3M3
      Conserved Domains (5) summary
      cd06186
      Location:12361415
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd09820
      Location:41594
      dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
      cd00051
      Location:831892
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01794
      Location:10561189
      Ferric_reduct; Ferric reductase like transmembrane component
      cl25352
      Location:778936
      EFh_PEF; The penta-EF hand (PEF) family
    10. XM_026439464.1XP_026295249.1  dual oxidase isoform X4

      UniProtKB/TrEMBL
      A0A7M7L1F4, A0A8B8GWG0, A7E3M3
      Conserved Domains (5) summary
      cd06186
      Location:10401219
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd00051
      Location:635696
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01794
      Location:860993
      Ferric_reduct; Ferric reductase like transmembrane component
      cl14561
      Location:1398
      An_peroxidase_like; Animal heme peroxidases and related proteins
      cl25352
      Location:582740
      EFh_PEF; The penta-EF hand (PEF) family