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    RMDN3 regulator of microtubule dynamics 3 [ Homo sapiens (human) ]

    Gene ID: 55177, updated on 6-Jun-2024

    Summary

    Official Symbol
    RMDN3provided by HGNC
    Official Full Name
    regulator of microtubule dynamics 3provided by HGNC
    Primary source
    HGNC:HGNC:25550
    See related
    Ensembl:ENSG00000137824 MIM:611873; AllianceGenome:HGNC:25550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RMD3; RMD-3; FAM82C; FAM82A2; ptpip51
    Summary
    Enables microtubule binding activity. Involved in cellular calcium ion homeostasis. Located in several cellular components, including intercellular bridge; mitochondrial outer membrane; and spindle. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in small intestine (RPKM 16.9), lung (RPKM 14.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RMDN3 in Genome Data Viewer
    Location:
    15q15.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (40735887..40755254, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (38541582..38561277, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41028085..41047452, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene kinetochore scaffold 1 Neighboring gene RNA, 7SL, cytoplasmic 376, pseudogene Neighboring gene MPRA-validated peak2302 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:40986424-40987021 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40987619-40988216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40988217-40988813 Neighboring gene RAD51 antisense RNA 1 Neighboring gene RAD51 recombinase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41032727-41033599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6340 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:41046843-41047057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9261 Neighboring gene uncharacterized LOC124903474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41055946-41056811 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41057589-41058378 Neighboring gene SUMO2 pseudogene 15 Neighboring gene DnaJ heat shock protein family (Hsp40) member C17 Neighboring gene GTP cyclohydrolase I feedback regulator

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10579

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
     
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitotic spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in organelle membrane contact site IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    regulator of microtubule dynamics protein 3
    Names
    TCPTP-interacting protein 51
    cerebral protein 10
    family with sequence similarity 82, member A2
    family with sequence similarity 82, member C
    microtubule-associated protein
    protein tyrosine phosphatase-interacting protein 51

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304802.2NP_001291731.1  regulator of microtubule dynamics protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001291731.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA772280, AK092058, DA280017
      Consensus CDS
      CCDS10063.1
      UniProtKB/Swiss-Prot
      A9UMZ9, B3KRR3, Q6ZWE9, Q96H23, Q96SD6, Q96TC7, Q9H6G1, Q9NVQ6
      UniProtKB/TrEMBL
      B3KUI4
      Conserved Domains (1) summary
      sd00006
      Location:362412
      TPR; TPR repeat [structural motif]
    2. NM_001323894.2NP_001310823.1  regulator of microtubule dynamics protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC012476
      Consensus CDS
      CCDS10063.1
      UniProtKB/Swiss-Prot
      A9UMZ9, B3KRR3, Q6ZWE9, Q96H23, Q96SD6, Q96TC7, Q9H6G1, Q9NVQ6
      UniProtKB/TrEMBL
      B3KUI4
      Conserved Domains (1) summary
      sd00006
      Location:362412
      TPR; TPR repeat [structural motif]
    3. NM_001323895.2NP_001310824.1  regulator of microtubule dynamics protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC012476
      UniProtKB/TrEMBL
      B3KUI4
      Conserved Domains (1) summary
      sd00006
      Location:233283
      TPR; TPR repeat [structural motif]
    4. NM_001323896.2NP_001310825.1  regulator of microtubule dynamics protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC012476
      UniProtKB/TrEMBL
      B3KUI4
    5. NM_001323897.2NP_001310826.1  regulator of microtubule dynamics protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC012476
      UniProtKB/TrEMBL
      B3KUI4
    6. NM_018145.3NP_060615.1  regulator of microtubule dynamics protein 3 isoform 1

      See identical proteins and their annotated locations for NP_060615.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents transcript variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC063844, DA280017
      Consensus CDS
      CCDS10063.1
      UniProtKB/Swiss-Prot
      A9UMZ9, B3KRR3, Q6ZWE9, Q96H23, Q96SD6, Q96TC7, Q9H6G1, Q9NVQ6
      UniProtKB/TrEMBL
      B3KUI4
      Related
      ENSP00000342493.3, ENST00000338376.8
      Conserved Domains (1) summary
      sd00006
      Location:362412
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      40735887..40755254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521755.3XP_011520057.1  regulator of microtubule dynamics protein 3 isoform X1

      UniProtKB/TrEMBL
      H0YMB1
      Related
      ENSP00000453535.1, ENST00000558232.5
      Conserved Domains (1) summary
      sd00006
      Location:156206
      TPR; TPR repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      38541582..38561277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378358.1XP_054234333.1  regulator of microtubule dynamics protein 3 isoform X1

      UniProtKB/TrEMBL
      H0YMB1