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    ANKZF1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 [ Homo sapiens (human) ]

    Gene ID: 55139, updated on 10-Dec-2024

    Summary

    Official Symbol
    ANKZF1provided by HGNC
    Official Full Name
    ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1provided by HGNC
    Primary source
    HGNC:HGNC:25527
    See related
    Ensembl:ENSG00000163516 MIM:617541; AllianceGenome:HGNC:25527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Vms1; ZNF744
    Summary
    Enables RNA endonuclease activity and catalytic activity, acting on a tRNA. Involved in cellular response to hydrogen peroxide; protein quality control for misfolded or incompletely synthesized proteins; and rescue of stalled ribosome. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 19.0), spleen (RPKM 18.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ANKZF1 in Genome Data Viewer
    Location:
    2q35
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (219229806..219236679)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (219714571..219721444)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220094528..220101401)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily B member 6 (LAN blood group) Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:220082897-220083764 Neighboring gene autophagy related 9A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220093298-220093846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220093847-220094394 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:220094395-220094942 Neighboring gene galactosidase beta 1 like Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:220109882-220110464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17145 Neighboring gene serine/threonine kinase 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12351 Neighboring gene tubulin alpha 4a Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17148 Neighboring gene tubulin alpha 4b

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10415, FLJ13144

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables catalytic activity, acting on a tRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 

    General protein information

    Preferred Names
    tRNA endonuclease ANKZF1
    Names
    ankyrin repeat and zinc finger domain containing 1
    ankyrin repeat and zinc finger domain-containing protein 1
    zinc finger protein 744

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042410.2NP_001035869.1  tRNA endonuclease ANKZF1 isoform 1

      See identical proteins and their annotated locations for NP_001035869.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC068946, AK023206, BC028334, DA899467
      Consensus CDS
      CCDS42821.1
      UniProtKB/Swiss-Prot
      Q9H8Y5, Q9NVZ4
      Related
      ENSP00000386337.3, ENST00000410034.7
      Conserved Domains (5) summary
      smart00451
      Location:69103
      ZnF_U1; U1-like zinc finger
      cd00204
      Location:495578
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00020
      Location:7496
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13637
      Location:495555
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:495532
      ANK; ANK repeat [structural motif]
    2. NM_001282792.2NP_001269721.1  tRNA endonuclease ANKZF1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks three consecutive exons in the 5' region, and initiates translation at a downstream AUG codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AA482007, AC068946, AK225275, BC028334, DA226194
      Consensus CDS
      CCDS63129.1
      UniProtKB/TrEMBL
      B8ZZS4
      Related
      ENSP00000386815.1, ENST00000409849.5
      Conserved Domains (3) summary
      cd00204
      Location:285368
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam13637
      Location:285345
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:285322
      ANK; ANK repeat [structural motif]
    3. NM_018089.3NP_060559.2  tRNA endonuclease ANKZF1 isoform 1

      See identical proteins and their annotated locations for NP_060559.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1)represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC068946, BC008948, BC028334, DA226194
      Consensus CDS
      CCDS42821.1
      UniProtKB/Swiss-Prot
      Q9H8Y5, Q9NVZ4
      Related
      ENSP00000321617.5, ENST00000323348.10
      Conserved Domains (5) summary
      smart00451
      Location:69103
      ZnF_U1; U1-like zinc finger
      cd00204
      Location:495578
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00020
      Location:7496
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13637
      Location:495555
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:495532
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      219229806..219236679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511392.4XP_011509694.1  tRNA endonuclease ANKZF1 isoform X1

      Conserved Domains (5) summary
      smart00451
      Location:69103
      ZnF_U1; U1-like zinc finger
      cd00204
      Location:494577
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00020
      Location:7496
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13637
      Location:494554
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:494531
      ANK; ANK repeat [structural motif]
    2. XM_017004421.3XP_016859910.1  tRNA endonuclease ANKZF1 isoform X5

    3. XM_047444866.1XP_047300822.1  tRNA endonuclease ANKZF1 isoform X6

    4. XM_047444865.1XP_047300821.1  tRNA endonuclease ANKZF1 isoform X4

    5. XM_047444864.1XP_047300820.1  tRNA endonuclease ANKZF1 isoform X3

    6. XM_005246663.4XP_005246720.1  tRNA endonuclease ANKZF1 isoform X2

      Conserved Domains (5) summary
      smart00451
      Location:438
      ZnF_U1; U1-like zinc finger
      cd00204
      Location:430513
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00020
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13637
      Location:430490
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:430467
      ANK; ANK repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      219714571..219721444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342737.1XP_054198712.1  tRNA endonuclease ANKZF1 isoform X1

    2. XM_054342741.1XP_054198716.1  tRNA endonuclease ANKZF1 isoform X5

    3. XM_054342742.1XP_054198717.1  tRNA endonuclease ANKZF1 isoform X6

    4. XM_054342740.1XP_054198715.1  tRNA endonuclease ANKZF1 isoform X4

    5. XM_054342739.1XP_054198714.1  tRNA endonuclease ANKZF1 isoform X3

    6. XM_054342738.1XP_054198713.1  tRNA endonuclease ANKZF1 isoform X2