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    WRAP53 WD repeat containing antisense to TP53 [ Homo sapiens (human) ]

    Gene ID: 55135, updated on 11-Jun-2021

    Summary

    Official Symbol
    WRAP53provided by HGNC
    Official Full Name
    WD repeat containing antisense to TP53provided by HGNC
    Primary source
    HGNC:HGNC:25522
    See related
    Ensembl:ENSG00000141499 MIM:612661
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DKCB3; TCAB1; WDR79
    Summary
    This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]
    Expression
    Ubiquitous expression in lymph node (RPKM 2.8), testis (RPKM 2.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See WRAP53 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7686071..7703502)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7589389..7606820)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene sex hormone binding globulin Neighboring gene spermidine/spermine N1-acetyltransferase family member 2 Neighboring gene ATPase Na+/K+ transporting subunit beta 2 Neighboring gene tumor protein p53 Neighboring gene ephrin B3 Neighboring gene dynein axonemal heavy chain 2 Neighboring gene ribosomal protein L29 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10385

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables telomerase RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables telomerase RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Cajal body organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Cajal body organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in RNA folding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of double-strand break repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of double-strand break repair via nonhomologous end joining IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of establishment of protein localization to telomere IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of telomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of telomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to Cajal body TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in scaRNA localization to Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in scaRNA localization to Cajal body IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in telomerase RNA localization to Cajal body HMP PubMed 
    involved_in telomerase RNA localization to Cajal body IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in telomere formation via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in telomere maintenance via telomerase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in telomere maintenance via telomerase TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Cajal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Cajal body IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of telomerase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    telomerase Cajal body protein 1
    Names
    WD repeat-containing protein 79
    WD repeat-containing protein WRAP53
    WD40 protein Wrap53
    WD40 repeat-containing protein antisense to TP53
    WD40 repeat-containing protein encoding RNA antisense to p53
    WRAP53beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028245.1 RefSeqGene

      Range
      5001..22432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_375

    mRNA and Protein(s)

    1. NM_001143990.2NP_001137462.1  telomerase Cajal body protein 1

      See identical proteins and their annotated locations for NP_001137462.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as WRAP53gamma) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      DQ431241
      Consensus CDS
      CCDS11119.1
      UniProtKB/Swiss-Prot
      Q9BUR4
      Related
      ENSP00000397219.2, ENST00000431639.6
      Conserved Domains (2) summary
      sd00039
      Location:175223
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:175480
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001143991.2NP_001137463.1  telomerase Cajal body protein 1

      See identical proteins and their annotated locations for NP_001137463.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as WRAP53alpha) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC087388, AY766322
      Consensus CDS
      CCDS11119.1
      UniProtKB/Swiss-Prot
      Q9BUR4
      Related
      ENSP00000411061.2, ENST00000457584.6
      Conserved Domains (2) summary
      sd00039
      Location:175223
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:175480
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001143992.2NP_001137464.1  telomerase Cajal body protein 1

      See identical proteins and their annotated locations for NP_001137464.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as WRAP53beta) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      DQ431240
      Consensus CDS
      CCDS11119.1
      UniProtKB/Swiss-Prot
      Q9BUR4
      Related
      ENSP00000379727.3, ENST00000396463.7
      Conserved Domains (2) summary
      sd00039
      Location:175223
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:175480
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. NM_018081.2NP_060551.2  telomerase Cajal body protein 1

      See identical proteins and their annotated locations for NP_060551.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK225411, DQ431240
      Consensus CDS
      CCDS11119.1
      UniProtKB/Swiss-Prot
      Q9BUR4
      Related
      ENSP00000324203.5, ENST00000316024.9
      Conserved Domains (2) summary
      sd00039
      Location:175223
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:175480
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      7686071..7703502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450825.1XP_024306593.1  telomerase Cajal body protein 1 isoform X3

      Related
      ENSP00000432991.1, ENST00000498311.5
    2. XM_024450824.1XP_024306592.1  telomerase Cajal body protein 1 isoform X2

      Conserved Domains (2) summary
      COG2319
      Location:54216
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:65101
      7WD40; WD40 repeat [structural motif]
    3. XM_011523952.2XP_011522254.1  telomerase Cajal body protein 1 isoform X1

      Conserved Domains (3) summary
      COG2319
      Location:27267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:68110
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:27267
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_001752551.2 RNA Sequence

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