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    TTC22 tetratricopeptide repeat domain 22 [ Homo sapiens (human) ]

    Gene ID: 55001, updated on 5-Mar-2024

    Summary

    Official Symbol
    TTC22provided by HGNC
    Official Full Name
    tetratricopeptide repeat domain 22provided by HGNC
    Primary source
    HGNC:HGNC:26067
    See related
    Ensembl:ENSG00000006555 AllianceGenome:HGNC:26067
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a protein with seven tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]
    Expression
    Biased expression in esophagus (RPKM 8.5), colon (RPKM 4.0) and 12 other tissues See more
    Orthologs
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    Genomic context

    Location:
    1p32.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (54779712..54801323, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (54659937..54681544, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (55245385..55266996, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MROH7-TTC4 readthrough (NMD candidate) Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:55181271-55181772 Neighboring gene tetratricopeptide repeat domain 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:55229956-55230579 Neighboring gene prolyl-tRNA synthetase 2, mitochondrial Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55246797-55247339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55247340-55247881 Neighboring gene uncharacterized LOC124904182 Neighboring gene Sharpr-MPRA regulatory region 10932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55261394-55261933 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55261934-55262472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 923 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 924 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55266799-55267564 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55277747-55278246 Neighboring gene ciliary microtubule associated protein 2 Neighboring gene uncharacterized LOC124904183 Neighboring gene MPRA-validated peak246 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55316729-55317230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55317231-55317730 Neighboring gene 24-dehydrocholesterol reductase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55348920-55349489 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:55352395-55352896

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    tetratricopeptide repeat protein 22
    Names
    TPR repeat protein 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029054.2 RefSeqGene

      Range
      5000..26611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001114108.2NP_001107580.1  tetratricopeptide repeat protein 22 isoform 1

      See identical proteins and their annotated locations for NP_001107580.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC096536, AL139244
      Consensus CDS
      CCDS44152.1
      UniProtKB/Swiss-Prot
      Q5TAA0, Q9NWT4
      Related
      ENSP00000360323.4, ENST00000371276.9
      Conserved Domains (1) summary
      sd00006
      Location:6595
      TPR; TPR repeat [structural motif]
    2. NM_017904.4NP_060374.2  tetratricopeptide repeat protein 22 isoform 2

      See identical proteins and their annotated locations for NP_060374.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC096536, AL139244
      Consensus CDS
      CCDS598.1
      UniProtKB/Swiss-Prot
      Q5TAA0
      Related
      ENSP00000360321.4, ENST00000371274.8
      Conserved Domains (1) summary
      sd00006
      Location:6595
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      54779712..54801323 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541671.3XP_011539973.1  tetratricopeptide repeat protein 22 isoform X1

      Conserved Domains (1) summary
      sd00006
      Location:294324
      TPR; TPR repeat [structural motif]
    2. XM_017001582.2XP_016857071.1  tetratricopeptide repeat protein 22 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      54659937..54681544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337293.1XP_054193268.1  tetratricopeptide repeat protein 22 isoform X1

    2. XM_054337294.1XP_054193269.1  tetratricopeptide repeat protein 22 isoform X2