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    ULK4 unc-51 like kinase 4 [ Homo sapiens (human) ]

    Gene ID: 54986, updated on 17-Jun-2024

    Summary

    Official Symbol
    ULK4provided by HGNC
    Official Full Name
    unc-51 like kinase 4provided by HGNC
    Primary source
    HGNC:HGNC:15784
    See related
    Ensembl:ENSG00000168038 MIM:617010; AllianceGenome:HGNC:15784
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM7C1; REC01035
    Summary
    This gene encodes a member of the unc-51-like serine/threonine kinase (STK) family. Members of this protein family play a role in neuronal growth and endocytosis. The encoded protein is likely involved in neurite branching, neurite elongation and neuronal migration. Genome-wide association studies (GWAS) indicate an association of variations in this gene with blood pressure and hypertension. Sequence variations in this gene may also be be associated with psychiatric disorders, including schizophrenia and bipolar disorder. Pseudogenes associated with this gene have been identified and are located on chromosome 15. [provided by RefSeq, Jul 2016]
    Expression
    Broad expression in testis (RPKM 5.0), thyroid (RPKM 0.8) and 16 other tissues See more
    Orthologs
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    Genomic context

    See ULK4 in Genome Data Viewer
    Location:
    3p22.1
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (41246599..41962103, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (41255217..41980057, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (41288090..42003595, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14236 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:41236485-41237684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:41240699-41241645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19725 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:41265899-41267098 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:41274918-41276117 Neighboring gene mitochondrial ribosomal protein S31 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:41290696-41291196 Neighboring gene uncharacterized LOC105377046 Neighboring gene catenin beta 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:41404251-41405010 Neighboring gene rRNA-processing protein FCF1 homolog Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:41549167-41550366 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:41560057-41560744 Neighboring gene NANOG hESC enhancer GRCh37_chr3:41670520-41671021 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:41737391-41737574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:41752509-41753118 Neighboring gene RN7SK pseudogene 58 Neighboring gene ATPase H+ transporting V0 subunit e1 pseudogene 2 Neighboring gene uncharacterized LOC124900553 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:41967055-41967555 Neighboring gene MPRA-validated peak4618 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19727 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:42040771-42040982 Neighboring gene ribosomal protein L36 pseudogene 20 Neighboring gene uncharacterized LOC107986077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19728 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14239 Neighboring gene gem nuclear organelle associated protein 2 pseudogene 2 Neighboring gene trafficking kinesin protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk.
    EBI GWAS Catalog
    Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.
    EBI GWAS Catalog
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    EBI GWAS Catalog
    Genome-wide association study of blood pressure and hypertension.
    EBI GWAS Catalog
    The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with ULK4 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20574, DKFZp434E1822

    General protein information

    Preferred Names
    serine/threonine-protein kinase ULK4
    NP_001309429.1
    NP_001309430.1
    NP_060356.2
    XP_024309380.1
    XP_047304373.1
    XP_054203002.1
    XP_054203003.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051047.1 RefSeqGene

      Range
      5918..721422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001322500.2NP_001309429.1  serine/threonine-protein kinase ULK4 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC097356, AC099059, AC099537, AC104305, AC137935
      Conserved Domains (4) summary
      smart00220
      Location:4279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00020
      Location:646756
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd14010
      Location:3280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
      cl10013
      Location:486563
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    2. NM_001322501.2NP_001309430.1  serine/threonine-protein kinase ULK4 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC097356, AC099059, AC099537, AC104305, AC104307, AC137935, BC018795
      Conserved Domains (2) summary
      cd00020
      Location:344454
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cl10013
      Location:184261
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    3. NM_017886.4NP_060356.2  serine/threonine-protein kinase ULK4 isoform 1

      See identical proteins and their annotated locations for NP_060356.2

      Status: REVIEWED

      Source sequence(s)
      AC104305, AC137935, AK304341, BC018795, HY051714
      Consensus CDS
      CCDS43071.1
      UniProtKB/Swiss-Prot
      A6NF15, B3KSE5, B4E2M4, Q8IW79, Q96C45, Q9NWV6, Q9UF96
      Related
      ENSP00000301831.4, ENST00000301831.9
      Conserved Domains (4) summary
      smart00220
      Location:4279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00020
      Location:646756
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd14010
      Location:3280
      STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
      cl10013
      Location:486563
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

    RNA

    1. NR_136342.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC097356, AC099059, AC099537, AC104305, AC104307, AC137935, BC018795

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      41246599..41962103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448417.1XP_047304373.1  serine/threonine-protein kinase ULK4 isoform X1

    2. XM_024453612.2XP_024309380.1  serine/threonine-protein kinase ULK4 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      41255217..41980057 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347027.1XP_054203002.1  serine/threonine-protein kinase ULK4 isoform X1

    2. XM_054347028.1XP_054203003.1  serine/threonine-protein kinase ULK4 isoform X2