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    HCFC1R1 host cell factor C1 regulator 1 [ Homo sapiens (human) ]

    Gene ID: 54985, updated on 17-Jun-2024

    Summary

    Official Symbol
    HCFC1R1provided by HGNC
    Official Full Name
    host cell factor C1 regulator 1provided by HGNC
    Primary source
    HGNC:HGNC:21198
    See related
    Ensembl:ENSG00000103145 MIM:618818; AllianceGenome:HGNC:21198
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HPIP
    Summary
    Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney (RPKM 18.6), prostate (RPKM 18.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HCFC1R1 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3022620..3024286, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3049192..3050858, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3072621..3074287, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3065208-3065772 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3066992-3067588 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3067589-3068185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3068783-3069378 Neighboring gene claudin 6 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:3070698-3071897 Neighboring gene TNF receptor superfamily member 12A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10291 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3073371-3074015 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3074016-3074659 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3076940-3077746 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7105 Neighboring gene THO complex subunit 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3079359-3080163 Neighboring gene BICD family like cargo adaptor 2 Neighboring gene uncharacterized LOC100128770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10293 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3087655-3088542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7107 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3097443-3098022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3099514-3100106 Neighboring gene matrix metallopeptidase 25 Neighboring gene sialidase-like Neighboring gene MMP25 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7109 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7111

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20568, MGC70711, MGC99622

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    host cell factor C1 regulator 1
    Names
    HCF-1 beta-propeller-interacting protein
    host cell factor C1 regulator 1 (XPO1 dependent)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002017.2NP_001002017.1  host cell factor C1 regulator 1 isoform 2

      See identical proteins and their annotated locations for NP_001002017.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
      Source sequence(s)
      BC064026, BM790570, BU633901
      Consensus CDS
      CCDS32375.1
      UniProtKB/TrEMBL
      B4DES3
      Related
      ENSP00000459178.1, ENST00000574151.5
      Conserved Domains (1) summary
      pfam15226
      Location:2113
      HPIP; HCF-1 beta-propeller-interacting protein family
    2. NM_001002018.2NP_001002018.1  host cell factor C1 regulator 1 isoform 1

      See identical proteins and their annotated locations for NP_001002018.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 3, and 4 encode the same isoform (1).
      Source sequence(s)
      BC064026, BM790570, BU633901
      Consensus CDS
      CCDS10490.1
      UniProtKB/Swiss-Prot
      D3DUA7, Q68EN7, Q9NWW0
      UniProtKB/TrEMBL
      I3L174
      Related
      ENSP00000458628.1, ENST00000573842.1
      Conserved Domains (1) summary
      pfam15226
      Location:2132
      HPIP; HCF-1 beta-propeller-interacting protein family
    3. NM_001288665.1NP_001275594.1  host cell factor C1 regulator 1 isoform 1

      See identical proteins and their annotated locations for NP_001275594.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 3, and 4 encode the same isoform (1).
      Source sequence(s)
      BC064026, BM790570, BU633901
      Consensus CDS
      CCDS10490.1
      UniProtKB/Swiss-Prot
      D3DUA7, Q68EN7, Q9NWW0
      UniProtKB/TrEMBL
      I3L174
      Related
      ENSP00000460639.1, ENST00000574980.5
      Conserved Domains (1) summary
      pfam15226
      Location:2132
      HPIP; HCF-1 beta-propeller-interacting protein family
    4. NM_001288666.1NP_001275595.1  host cell factor C1 regulator 1 isoform 2

      See identical proteins and their annotated locations for NP_001275595.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
      Source sequence(s)
      BC064026, BM790570, BU633901
      Consensus CDS
      CCDS32375.1
      UniProtKB/TrEMBL
      B4DES3
      Conserved Domains (1) summary
      pfam15226
      Location:2113
      HPIP; HCF-1 beta-propeller-interacting protein family
    5. NM_001288667.1NP_001275596.1  host cell factor C1 regulator 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an exon and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (3) has a distinct and shorter internal segment, compared to isoform 1.
      Source sequence(s)
      BC064026, BM790570, BU633901, CN427571
      Consensus CDS
      CCDS73815.1
      UniProtKB/TrEMBL
      B4DES3, J3KNY1
      Related
      ENSP00000346708.3, ENST00000354679.3
      Conserved Domains (1) summary
      pfam15226
      Location:2130
      HPIP; HCF-1 beta-propeller-interacting protein family
    6. NM_001288668.1NP_001275597.1  host cell factor C1 regulator 1 isoform 4

      See identical proteins and their annotated locations for NP_001275597.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      BC064026, BM790570, BU633901, CN427571
      UniProtKB/Swiss-Prot
      Q9NWW0
      Related
      ENST00000573095.1
      Conserved Domains (1) summary
      pfam15226
      Location:171
      HPIP; HCF-1 beta-propeller-interacting protein family
    7. NM_001308070.1NP_001294999.1  host cell factor C1 regulator 1 isoform 5

      See identical proteins and their annotated locations for NP_001294999.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses an alternate splice site in the 5' UTR which results in the use of a downstream start codon compared to variant 1. The encoded isoform (5) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC108134, BU623445, BU633901
      Consensus CDS
      CCDS76810.1
      UniProtKB/TrEMBL
      I3L1N5
      Related
      ENSP00000458971.1, ENST00000572355.5
      Conserved Domains (1) summary
      pfam15226
      Location:192
      HPIP; HCF-1 beta-propeller-interacting protein family
    8. NM_017885.4NP_060355.1  host cell factor C1 regulator 1 isoform 1

      See identical proteins and their annotated locations for NP_060355.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 3, and 4 encode the same isoform.
      Source sequence(s)
      AC108134
      Consensus CDS
      CCDS10490.1
      UniProtKB/Swiss-Prot
      D3DUA7, Q68EN7, Q9NWW0
      UniProtKB/TrEMBL
      I3L174
      Related
      ENSP00000248089.4, ENST00000248089.8
      Conserved Domains (1) summary
      pfam15226
      Location:2132
      HPIP; HCF-1 beta-propeller-interacting protein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      3022620..3024286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522559.4XP_011520861.1  host cell factor C1 regulator 1 isoform X2

      See identical proteins and their annotated locations for XP_011520861.1

      Conserved Domains (1) summary
      pfam15226
      Location:171
      HPIP; HCF-1 beta-propeller-interacting protein family
    2. XM_047434301.1XP_047290257.1  host cell factor C1 regulator 1 isoform X2

    3. XM_017023384.2XP_016878873.1  host cell factor C1 regulator 1 isoform X1

      UniProtKB/TrEMBL
      B4DES3, J3KNY1
      Conserved Domains (1) summary
      pfam15226
      Location:2130
      HPIP; HCF-1 beta-propeller-interacting protein family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      3049192..3050858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380624.1XP_054236599.1  host cell factor C1 regulator 1 isoform X2

    2. XM_054380625.1XP_054236600.1  host cell factor C1 regulator 1 isoform X2

    3. XM_054380623.1XP_054236598.1  host cell factor C1 regulator 1 isoform X1

      UniProtKB/TrEMBL
      B4DES3, J3KNY1