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    MRPL16 mitochondrial ribosomal protein L16 [ Homo sapiens (human) ]

    Gene ID: 54948, updated on 17-Jun-2024

    Summary

    Official Symbol
    MRPL16provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein L16provided by HGNC
    Primary source
    HGNC:HGNC:14476
    See related
    Ensembl:ENSG00000166902 MIM:611829; AllianceGenome:HGNC:14476
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L16mt; uL16m; MRP-L16; PNAS-111
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in heart (RPKM 22.7), adrenal (RPKM 21.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See MRPL16 in Genome Data Viewer
    Location:
    11q12.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (59806140..59810778, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (59757431..59762069, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (59573613..59578251, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory regions 192 and 10030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3369 Neighboring gene olfactory receptor family 10 subfamily V member 2 pseudogene Neighboring gene syntaxin 3 Neighboring gene fatty acid binding protein 5 pseudogene 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4762 Neighboring gene cobalamin binding intrinsic factor Neighboring gene transcobalamin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20484

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of mitochondrial large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    large ribosomal subunit protein uL16m
    Names
    39S ribosomal protein L16, mitochondrial
    mitochondrial large ribosomal subunit protein uL16m
    NP_060310.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017840.4NP_060310.1  large ribosomal subunit protein uL16m

      See identical proteins and their annotated locations for NP_060310.1

      Status: REVIEWED

      Source sequence(s)
      AA454132, AB049642
      Consensus CDS
      CCDS7976.1
      UniProtKB/Swiss-Prot
      Q9BYD0, Q9HB70, Q9NX20
      Related
      ENSP00000300151.4, ENST00000300151.5
      Conserved Domains (1) summary
      pfam00252
      Location:60190
      Ribosomal_L16; Ribosomal protein L16p/L10e

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      59806140..59810778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      59757431..59762069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)