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    TASOR2 transcription activation suppressor family member 2 [ Homo sapiens (human) ]

    Gene ID: 54906, updated on 5-May-2024

    Summary

    Official Symbol
    TASOR2provided by HGNC
    Official Full Name
    transcription activation suppressor family member 2provided by HGNC
    Primary source
    HGNC:HGNC:23484
    See related
    Ensembl:ENSG00000108021 AllianceGenome:HGNC:23484
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM208B; C10orf18; bA318E3.2
    Summary
    Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 8.3), thyroid (RPKM 5.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    10p15.1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (5684838..5763740)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (5688634..5767529)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (5726801..5805703)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984199 Neighboring gene RNA, 7SL, cytoplasmic 445, pseudogene Neighboring gene ankyrin repeat and SOCS box containing 13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:5702971-5703707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2083 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2927 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2085 Neighboring gene Sharpr-MPRA regulatory region 2494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:5793844-5794458 Neighboring gene MPRA-validated peak855 silencer Neighboring gene GDP dissociation inhibitor 2 Neighboring gene nuclear receptor binding factor 2 pseudogene 5 Neighboring gene uncharacterized LOC124902367 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:5854819-5855411

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20360, DKFZp781E1986

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of gene expression, epigenetic IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    protein TASOR 2
    Names
    family with sequence similarity 208 member B
    protein FAM208B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021250.2 RefSeqGene

      Range
      5002..83904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001321783.2NP_001308712.2  protein TASOR 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL365356, AL596094
      Consensus CDS
      CCDS41485.1
      UniProtKB/Swiss-Prot
      Q2YD91, Q5VWN5, Q5VWN6, Q6ZRQ8, Q8IVG4, Q9BUZ7, Q9H5J9, Q9H7A4, Q9H996, Q9NXA1
      UniProtKB/TrEMBL
      A0A8Q3SI68
      Related
      ENSP00000512130.1, ENST00000695737.1
      Conserved Domains (2) summary
      pfam12480
      Location:94167
      DUF3699; Protein of unknown function (DUF3699)
      pfam12509
      Location:552701
      DUF3715; Protein of unknown function (DUF3715)
    2. NM_001321784.2NP_001308713.2  protein TASOR 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL365356, AL596094
      Consensus CDS
      CCDS41485.1
      UniProtKB/Swiss-Prot
      Q2YD91, Q5VWN5, Q5VWN6, Q6ZRQ8, Q8IVG4, Q9BUZ7, Q9H5J9, Q9H7A4, Q9H996, Q9NXA1
      UniProtKB/TrEMBL
      A0A8Q3SI68
      Related
      ENSP00000512207.1, ENST00000695834.1
      Conserved Domains (2) summary
      pfam12480
      Location:94167
      DUF3699; Protein of unknown function (DUF3699)
      pfam12509
      Location:552701
      DUF3715; Protein of unknown function (DUF3715)
    3. NM_001321785.2NP_001308714.2  protein TASOR 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL365356, AL596094
      Consensus CDS
      CCDS91209.1
      UniProtKB/TrEMBL
      A0A8Q3SI68, A0A8Q3SI84
      Related
      ENSP00000512206.1, ENST00000695833.1
      Conserved Domains (2) summary
      pfam12480
      Location:94167
      DUF3699; Protein of unknown function (DUF3699)
      pfam12509
      Location:471620
      DUF3715; Protein of unknown function (DUF3715)
    4. NM_001387328.1NP_001374257.1  protein TASOR 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL365356, AL596094
      Consensus CDS
      CCDS91208.1
      UniProtKB/TrEMBL
      A0A2R8YH03, A0A8V8TMN1
      Related
      ENSP00000496466.1, ENST00000645567.1
      Conserved Domains (2) summary
      pfam12480
      Location:309382
      DUF3699; Protein of unknown function (DUF3699)
      pfam12509
      Location:767916
      DUF3715; Protein of unknown function (DUF3715)
    5. NM_017782.5NP_060252.5  protein TASOR 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL365356, AL596094
      Consensus CDS
      CCDS41485.1
      UniProtKB/Swiss-Prot
      Q2YD91, Q5VWN5, Q5VWN6, Q6ZRQ8, Q8IVG4, Q9BUZ7, Q9H5J9, Q9H7A4, Q9H996, Q9NXA1
      UniProtKB/TrEMBL
      A0A8Q3SI68
      Related
      ENSP00000328426.5, ENST00000328090.9
      Conserved Domains (2) summary
      pfam12480
      Location:94167
      DUF3699; Protein of unknown function (DUF3699)
      pfam12509
      Location:552701
      DUF3715; Protein of unknown function (DUF3715)

    RNA

    1. NR_135800.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL365356, R42352

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      5684838..5763740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      5688634..5767529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)