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    IL17RD interleukin 17 receptor D [ Homo sapiens (human) ]

    Gene ID: 54756, updated on 17-Jun-2024

    Summary

    Official Symbol
    IL17RDprovided by HGNC
    Official Full Name
    interleukin 17 receptor Dprovided by HGNC
    Primary source
    HGNC:HGNC:17616
    See related
    Ensembl:ENSG00000144730 MIM:606807; AllianceGenome:HGNC:17616
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SEF; HH18; IL-17RD; IL17RLM
    Summary
    This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
    Expression
    Broad expression in endometrium (RPKM 8.3), testis (RPKM 6.2) and 14 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See IL17RD in Genome Data Viewer
    Location:
    3p14.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (57089982..57170317, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (57130265..57210589, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (57124010..57204345, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 3 Neighboring gene ARHGEF3 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:57040522-57041053 Neighboring gene Sharpr-MPRA regulatory region 6639 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:57049075-57049840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:57086410-57086910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:57086911-57087411 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:57097817-57098598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19985 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14477 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:57131244-57132443 Neighboring gene spermatogenesis associated 12 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:57144939-57145652 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr3:57162623-57163448 and GRCh37_chr3:57163449-57164275 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:57165102-57165928 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:57164276-57165101 Neighboring gene uncharacterized LOC105377101 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:57192947-57193632 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:57193633-57194316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14479 Neighboring gene ribosomal protein L19 pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:57218732-57218927 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:57233699-57234296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19986 Neighboring gene HESX homeobox 1 Neighboring gene uncharacterized LOC105377102 Neighboring gene adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 Neighboring gene ankyrin repeat and SOCS box containing 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ35755, MGC133309, DKFZp434N1928

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables interleukin-17 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of epithelial to mesenchymal transition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    interleukin-17 receptor D
    Names
    IL-17 receptor D
    IL17Rhom
    interleukin-17 receptor-like protein
    sef homolog
    similar expression to fgf genes

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047158.1 RefSeqGene

      Range
      9965..85336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001318864.2NP_001305793.1  interleukin-17 receptor D isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start site, compared to variant 2. It encodes a shorter isoform (b) which has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC097358, AF494211, BQ017683, HY005493
      Consensus CDS
      CCDS82790.1
      UniProtKB/TrEMBL
      B4DXM5
      Related
      ENSP00000322250.5, ENST00000320057.9
      Conserved Domains (2) summary
      pfam08357
      Location:212367
      SEFIR; SEFIR domain
      pfam16742
      Location:125
      IL17R_D_N; N-terminus of interleukin 17 receptor D
    2. NM_017563.5NP_060033.3  interleukin-17 receptor D isoform a precursor

      See identical proteins and their annotated locations for NP_060033.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the shorter transcript and encodes the longer isoform a (also known as hSef-a).
      Source sequence(s)
      AC097358, AF458067, AK302045, BQ017683, HY024286
      Consensus CDS
      CCDS2880.2
      UniProtKB/Swiss-Prot
      Q2NKP7, Q58EZ7, Q6RVF4, Q6UWI5, Q8N113, Q8NFM7, Q8NFS0, Q9UFA0
      Related
      ENSP00000296318.7, ENST00000296318.12
      Conserved Domains (2) summary
      pfam08357
      Location:356511
      SEFIR; SEFIR domain
      pfam16742
      Location:48169
      IL17R_D_N; N-terminus of interleukin 17 receptor D

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      57089982..57170317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448369.1XP_047304325.1  interleukin-17 receptor D isoform X1

      UniProtKB/TrEMBL
      B4DXM5
    2. XM_005265238.5XP_005265295.1  interleukin-17 receptor D isoform X2

      Conserved Domains (2) summary
      pfam08357
      Location:328483
      SEFIR; SEFIR domain
      pfam16742
      Location:20141
      IL17R_D_N; N-terminus of interleukin 17 receptor D
    3. XM_011533849.2XP_011532151.2  interleukin-17 receptor D isoform X1

      UniProtKB/TrEMBL
      B4DXM5
      Related
      ENSP00000417516.1, ENST00000463523.5
      Conserved Domains (2) summary
      pfam08357
      Location:212367
      SEFIR; SEFIR domain
      pfam16742
      Location:125
      IL17R_D_N; N-terminus of interleukin 17 receptor D

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      57130265..57210589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346953.1XP_054202928.1  interleukin-17 receptor D isoform X2

    2. XM_054346954.1XP_054202929.1  interleukin-17 receptor D isoform X1

      UniProtKB/TrEMBL
      B4DXM5
    3. XM_054346952.1XP_054202927.1  interleukin-17 receptor D isoform X1

      UniProtKB/TrEMBL
      B4DXM5