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    LY6K lymphocyte antigen 6 family member K [ Homo sapiens (human) ]

    Gene ID: 54742, updated on 17-Jun-2024

    Summary

    Official Symbol
    LY6Kprovided by HGNC
    Official Full Name
    lymphocyte antigen 6 family member Kprovided by HGNC
    Primary source
    HGNC:HGNC:24225
    See related
    Ensembl:ENSG00000160886 MIM:615093; AllianceGenome:HGNC:24225
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT97; ly-6K; URLC10; HSJ001348
    Summary
    Predicted to be involved in binding activity of sperm to zona pellucida. Predicted to act upstream of or within flagellated sperm motility. Predicted to be located in cell surface; cytoplasm; and plasma membrane. Predicted to be active in acrosomal vesicle. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 9.3), fat (RPKM 2.1) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See LY6K in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (142700111..142705127)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (143843499..143848515)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143781529..143786545)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19603 Neighboring gene prostate stem cell antigen Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143762658-143763304 Neighboring gene uncharacterized LOC124902032 Neighboring gene lncRNA associated with ovarian cancer 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19605 Neighboring gene thioesterase superfamily member 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143819807-143820373 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19606 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19607 Neighboring gene secreted LY6/PLAUR domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ35226

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in acrosomal vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    lymphocyte antigen 6K
    Names
    cancer/testis antigen 97
    lymphocyte antigen 6 complex, locus K
    up-regulated in lung cancer 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160354.2NP_001153826.1  lymphocyte antigen 6K isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region that causes a frameshift, compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      BC001291, BG491223, CB528496
      UniProtKB/Swiss-Prot
      Q17RY6
    2. NM_001160355.2NP_001153827.1  lymphocyte antigen 6K isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region that causes a frameshift, compared to variant 1. The resulting isoform (3) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AI740834, BC001291, BG491223
      Consensus CDS
      CCDS59114.1
      UniProtKB/Swiss-Prot
      Q17RY6
      Related
      ENSP00000429695.1, ENST00000519387.1
    3. NM_017527.4NP_059997.3  lymphocyte antigen 6K isoform 1 precursor

      See identical proteins and their annotated locations for NP_059997.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC108002, BC001291, BG491223
      Consensus CDS
      CCDS6385.2
      UniProtKB/Swiss-Prot
      G3V116, O15227, Q17RY6, Q9BVD7
      Related
      ENSP00000292430.6, ENST00000292430.10

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      142700111..142705127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005250990.6XP_005251047.1  lymphocyte antigen 6K isoform X2

    2. XM_005250989.6XP_005251046.1  lymphocyte antigen 6K isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      143843499..143848515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360724.1XP_054216699.1  lymphocyte antigen 6K isoform X2

    2. XM_054360723.1XP_054216698.1  lymphocyte antigen 6K isoform X1