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    Rcan1 regulator of calcineurin 1 [ Mus musculus (house mouse) ]

    Gene ID: 54720, updated on 22-Aug-2021

    Summary

    Official Symbol
    Rcan1provided by MGI
    Official Full Name
    regulator of calcineurin 1provided by MGI
    Primary source
    MGI:MGI:1890564
    See related
    Ensembl:ENSMUSG00000022951
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CS; Dsc; MCI; ADAP; CSP1; DSC1; RCN1; Dscr1; MCIP1; CALP1L; Adapt78
    Expression
    Ubiquitous expression in CNS E18 (RPKM 17.8), heart adult (RPKM 14.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rcan1 in Genome Data Viewer
    Location:
    16 C4; 16 53.6 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (92188839..92263057, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (92391951..92466169, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (92392198..92466391, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, Isk-related subfamily, member 1 Neighboring gene predicted gene, 30163 Neighboring gene predicted gene, 29805 Neighboring gene VISTA enhancer mm107 Neighboring gene predicted gene, 41498 Neighboring gene predicted gene, 46555 Neighboring gene RIKEN cDNA 2410124H12 gene Neighboring gene chloride intracellular channel 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • 2410048A02Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-dependent protein serine/threonine phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcineurin-NFAT signaling cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within calcineurin-NFAT signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within locomotion involved in locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to estrogen ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to ischemia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within response to stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within short-term memory IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within skeletal muscle fiber development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    calcipressin-1
    Names
    calcineurin inhibitor
    down syndrome critical region protein 1 homolog
    myocyte-enriched calcineurin-interacting protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081549.2NP_001075018.1  calcipressin-1 isoform 1

      See identical proteins and their annotated locations for NP_001075018.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK146764, BY276032, BY454038
      Consensus CDS
      CCDS37405.1
      UniProtKB/TrEMBL
      Q7TNY3
      Related
      ENSMUSP00000060394.9, ENSMUST00000060005.15
      Conserved Domains (1) summary
      pfam04847
      Location:75244
      Calcipressin; Calcipressin
    2. NM_019466.4NP_062339.2  calcipressin-1 isoform 2

      See identical proteins and their annotated locations for NP_062339.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC162305, AK077283, AK146764, BY454038
      Consensus CDS
      CCDS28337.1
      UniProtKB/Swiss-Prot
      Q9JHG6
      UniProtKB/TrEMBL
      Q542V6, Q7TNY3
      Related
      ENSMUSP00000023672.8, ENSMUST00000023672.10
      Conserved Domains (1) summary
      pfam04847
      Location:22191
      Calcipressin; Calcipressin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      92188839..92263057 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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