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    Rcan1 regulator of calcineurin 1 [ Mus musculus (house mouse) ]

    Gene ID: 54720, updated on 12-Aug-2018

    Summary

    Official Symbol
    Rcan1provided by MGI
    Official Full Name
    regulator of calcineurin 1provided by MGI
    Primary source
    MGI:MGI:1890564
    See related
    Ensembl:ENSMUSG00000022951
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CSP1; DSC1; RCN1; Dscr1; MCIP1; CALP1L; Adapt78
    Expression
    Ubiquitous expression in CNS E18 (RPKM 17.8), heart adult (RPKM 14.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rcan1 in Genome Data Viewer
    Location:
    16 C4; 16 53.6 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (92391951..92466169, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (92392198..92466391, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, Isk-related subfamily, member 1 Neighboring gene predicted gene, 30163 Neighboring gene predicted gene, 29805 Neighboring gene predicted gene, 41498 Neighboring gene predicted gene, 46556 Neighboring gene predicted gene, 46555 Neighboring gene RIKEN cDNA 2410124H12 gene Neighboring gene chloride intracellular channel 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • MicroRNAs in Cardiomyocyte Hypertrophy, organism-specific biosystem (from WikiPathways)
      MicroRNAs in Cardiomyocyte Hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted inter...
    • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
      Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • Oxytocin signaling pathway, conserved biosystem (from KEGG)
      Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
      Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • 2410048A02Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium-dependent protein serine/threonine phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    calcineurin-NFAT signaling cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    calcineurin-NFAT signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    locomotion involved in locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcineurin-NFAT signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to ischemia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    short-term memory IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    skeletal muscle fiber development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    calcipressin-1
    Names
    calcineurin inhibitor
    down syndrome critical region protein 1 homolog
    myocyte-enriched calcineurin-interacting protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081549.2NP_001075018.1  calcipressin-1 isoform 1

      See identical proteins and their annotated locations for NP_001075018.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK146764, BY276032, BY454038
      Consensus CDS
      CCDS37405.1
      UniProtKB/TrEMBL
      Q7TNY3
      Related
      ENSMUSP00000060394.8, ENSMUST00000060005.14
      Conserved Domains (1) summary
      pfam04847
      Location:75244
      Calcipressin; Calcipressin
    2. NM_019466.4NP_062339.2  calcipressin-1 isoform 2

      See identical proteins and their annotated locations for NP_062339.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC162305, AK077283, AK146764, BY454038
      Consensus CDS
      CCDS28337.1
      UniProtKB/Swiss-Prot
      Q9JHG6
      UniProtKB/TrEMBL
      Q542V6, Q7TNY3
      Related
      ENSMUSP00000023672.7, ENSMUST00000023672.9
      Conserved Domains (1) summary
      pfam04847
      Location:22191
      Calcipressin; Calcipressin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      92391951..92466169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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