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    Prdx5 peroxiredoxin 5 [ Mus musculus (house mouse) ]

    Gene ID: 54683, updated on 20-Jul-2021

    Summary

    Official Symbol
    Prdx5provided by MGI
    Official Full Name
    peroxiredoxin 5provided by MGI
    Primary source
    MGI:MGI:1859821
    See related
    Ensembl:ENSMUSG00000024953
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P; PLP; PMP; Prd; AOPP; PrxV; AOEB1; Pmp20; Prdx6; AOEB166
    Summary
    This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites may result in use of alternate in-frame translation start codons that generate alternate isoforms that are targeted to the mitochondrion or peroxisome/cytoplasm. [provided by RefSeq, Nov 2017]
    Expression
    Ubiquitous expression in kidney adult (RPKM 737.0), heart adult (RPKM 197.2) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Prdx5 in Genome Data Viewer
    Location:
    19 A; 19 5.08 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6884065..6887474, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6906697..6910106, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (6981309..6984135, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 88B Neighboring gene predicted gene, 54051 Neighboring gene tRNA methyltransferase 11-2 Neighboring gene estrogen related receptor, alpha Neighboring gene microRNA 6990 Neighboring gene cation channel sperm associated auxiliary subunit zeta

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase III transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables antioxidant activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables antioxidant activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peroxiredoxin activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peroxynitrite reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables thioredoxin peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables thioredoxin peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in NADPH oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in hydrogen peroxide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hydrogen peroxide catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reactive nitrogen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptosis involved in tissue homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisomal matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisomal matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peroxiredoxin-5, mitochondrial
    Names
    antioxidant enzyme B166
    liver tissue 2D-page spot 2D-0014IV
    peroxiredoxin 6
    peroxiredoxin V
    peroxisomal antioxidant enzyme
    peroxisomal membrane protein 20
    thioredoxin peroxidase PMP20
    thioredoxin reductase
    thioredoxin-dependent peroxiredoxin 5
    NP_001345373.1
    NP_036151.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358444.1NP_001345373.1  peroxiredoxin-5, mitochondrial isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter, distinct C-terminus than isoform 1.
      Source sequence(s)
      AC120557
      Related
      ENSMUSP00000158249.2, ENSMUST00000238095.2
      Conserved Domains (1) summary
      cd03013
      Location:54155
      PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...
    2. NM_012021.3NP_036151.1  peroxiredoxin-5, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_036151.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA208558, AC120557, AK003332, AK009858
      Consensus CDS
      CCDS29507.1
      UniProtKB/Swiss-Prot
      P99029
      Related
      ENSMUSP00000025904.6, ENSMUST00000025904.12
      Conserved Domains (1) summary
      cd03013
      Location:54208
      PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6884065..6887474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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