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    Paf1 Paf1, RNA polymerase II complex component [ Mus musculus (house mouse) ]

    Gene ID: 54624, updated on 19-Sep-2021

    Summary

    Official Symbol
    Paf1provided by MGI
    Official Full Name
    Paf1, RNA polymerase II complex componentprovided by MGI
    Primary source
    MGI:MGI:1923988
    See related
    Ensembl:ENSMUSG00000003437
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA675045; 5730511K23Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 57.2), ovary adult (RPKM 38.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Paf1 in Genome Data Viewer
    Location:
    7; 7 A3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28074998..28098813)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28392996..28399383)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (29178015..29184402)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene snoRNA AF357399 Neighboring gene ribosomal protein S16 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 2 Neighboring gene nuclear encoded tRNA isoleucine 16 (anticodon TAT) Neighboring gene zinc finger protein 36 Neighboring gene mediator complex subunit 29 Neighboring gene sterile alpha motif domain containing 4B Neighboring gene glia maturation factor, gamma

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ11123, MGC102062

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endodermal cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone H2B ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone modification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA polyadenylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nucleosome positioning ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of histone methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transcription elongation from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Cdc73/Paf1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Cdc73/Paf1 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of Cdc73/Paf1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in transcriptionally active chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    RNA polymerase II-associated factor 1 homolog
    Names
    Paf1, RNA polymerase II associated factor, homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019458.3NP_062331.2  RNA polymerase II-associated factor 1 homolog

      See identical proteins and their annotated locations for NP_062331.2

      Status: PROVISIONAL

      Source sequence(s)
      AC149606
      Consensus CDS
      CCDS21043.1
      UniProtKB/Swiss-Prot
      Q8K2T8
      Related
      ENSMUSP00000003529.9, ENSMUST00000003529.9
      Conserved Domains (1) summary
      pfam03985
      Location:30443
      Paf1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      28074998..28098813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153258.1XP_036009151.1  RNA polymerase II-associated factor 1 homolog isoform X1

      Conserved Domains (1) summary
      pfam03985
      Location:30443
      Paf1
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