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    DLL4 delta like canonical Notch ligand 4 [ Homo sapiens (human) ]

    Gene ID: 54567, updated on 11-Jul-2021

    Summary

    Official Symbol
    DLL4provided by HGNC
    Official Full Name
    delta like canonical Notch ligand 4provided by HGNC
    Primary source
    HGNC:HGNC:2910
    See related
    Ensembl:ENSG00000128917 MIM:605185
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AOS6; delta4; hdelta2
    Summary
    This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in placenta (RPKM 11.5), fat (RPKM 11.2) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DLL4 in Genome Data Viewer
    Location:
    15q15.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (40929340..40939073)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41221538..41231271)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene VPS18 core subunit of CORVET and HOPS complexes Neighboring gene uncharacterized LOC105370943 Neighboring gene ChaC glutathione specific gamma-glutamylcyclotransferase 1 Neighboring gene iron-sulfur cluster assembly 1 pseudogene 4 Neighboring gene uncharacterized LOC105370789

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Adams-Oliver syndrome 6
    MedGen: C4225271 OMIM: 616589 GeneReviews: Not available
    Compare labs
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC126344

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Notch binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling involved in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in aortic valve morphogenesis IC
    Inferred by Curator
    more info
    PubMed 
    involved_in blood circulation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in blood vessel lumenization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blood vessel remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in branching involved in blood vessel morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cardiac atrium morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cardiac ventricle morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to fibroblast growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to vascular endothelial growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dorsal aorta morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell migration involved in sprouting angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell migration involved in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in pericardium morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of neural precursor cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of neural retina development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in ventral spinal cord interneuron fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ventricular trabecula myocardium morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    delta-like protein 4
    Names
    delta 4
    delta ligand 4
    delta-like 4 homolog
    delta-like 4 protein
    drosophila Delta homolog 4
    notch ligand DLL4
    notch ligand delta-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046974.1 RefSeqGene

      Range
      5008..14741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1268

    mRNA and Protein(s)

    1. NM_019074.4NP_061947.1  delta-like protein 4 precursor

      See identical proteins and their annotated locations for NP_061947.1

      Status: REVIEWED

      Source sequence(s)
      AB036931, AI478830, BC106950, DA089757, HY291308
      Consensus CDS
      CCDS45232.1
      UniProtKB/Swiss-Prot
      Q9NR61
      Related
      ENSP00000249749.5, ENST00000249749.7
      Conserved Domains (3) summary
      cd00054
      Location:327360
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam01414
      Location:155217
      DSL; Delta serrate ligand
      pfam07657
      Location:2788
      MNNL; N terminus of Notch ligand

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

      Range
      40929340..40939073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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