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    GNL3L G protein nucleolar 3 like [ Homo sapiens (human) ]

    Gene ID: 54552, updated on 5-May-2024

    Summary

    Official Symbol
    GNL3Lprovided by HGNC
    Official Full Name
    G protein nucleolar 3 likeprovided by HGNC
    Primary source
    HGNC:HGNC:25553
    See related
    Ensembl:ENSG00000130119 MIM:300873; AllianceGenome:HGNC:25553
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GNL3B
    Summary
    The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in thyroid (RPKM 3.6), appendix (RPKM 3.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    Xp11.22
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (54530219..54645854)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (53821079..53936915)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (54556652..54593722)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene WNK lysine deficient protein kinase 3 Neighboring gene RNA, U6 small nuclear 434, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:54415213-54415877 Neighboring gene MPRA-validated peak7383 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29670 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:54505803-54506356 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20864 Neighboring gene TSR2 ribosome maturation factor Neighboring gene FYVE, RhoGEF and PH domain containing 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:54556053-54556573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29673 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:54665616-54666141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29675 Neighboring gene phosphoglycerate mutase family member 4 pseudogene 1 Neighboring gene inter-alpha-trypsin inhibitor heavy chain family member 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10613

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    part_of telomerase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    guanine nucleotide-binding protein-like 3-like protein
    Names
    G protein nucleolar 3B
    guanine nucleotide binding protein-like 3 (nucleolar)-like
    novel GTPase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021314.2 RefSeqGene

      Range
      5002..42072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184819.2NP_001171748.1  guanine nucleotide-binding protein-like 3-like protein

      See identical proteins and their annotated locations for NP_001171748.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK001475, AL391139, BC003603, BQ674906
      Consensus CDS
      CCDS14360.1
      UniProtKB/Swiss-Prot
      Q9NVN8
      UniProtKB/TrEMBL
      A0A6I8PL80
      Related
      ENSP00000354091.2, ENST00000360845.3
      Conserved Domains (2) summary
      cd04178
      Location:136307
      Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
      COG3596
      Location:251405
      YeeP; Predicted GTPase [General function prediction only]
    2. NM_019067.6NP_061940.1  guanine nucleotide-binding protein-like 3-like protein

      See identical proteins and their annotated locations for NP_061940.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK001475, AL391139, BQ674906
      Consensus CDS
      CCDS14360.1
      UniProtKB/Swiss-Prot
      Q9NVN8
      UniProtKB/TrEMBL
      A0A6I8PL80
      Related
      ENSP00000338573.4, ENST00000336470.8
      Conserved Domains (2) summary
      cd04178
      Location:136307
      Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
      COG3596
      Location:251405
      YeeP; Predicted GTPase [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      54530219..54645854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442190.1XP_047298146.1  guanine nucleotide-binding protein-like 3-like protein isoform X1

      UniProtKB/Swiss-Prot
      Q9NVN8
      Related
      ENSP00000501452.1, ENST00000674311.1
    2. XM_047442189.1XP_047298145.1  guanine nucleotide-binding protein-like 3-like protein isoform X1

      UniProtKB/Swiss-Prot
      Q9NVN8
      Related
      ENSP00000501411.1, ENST00000674498.1

    RNA

    1. XR_007068190.1 RNA Sequence

    2. XR_007068191.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      53821079..53936915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327276.1XP_054183251.1  guanine nucleotide-binding protein-like 3-like protein isoform X1

      UniProtKB/Swiss-Prot
      Q9NVN8
    2. XM_054327275.1XP_054183250.1  guanine nucleotide-binding protein-like 3-like protein isoform X1

      UniProtKB/Swiss-Prot
      Q9NVN8
    3. XM_054327274.1XP_054183249.1  guanine nucleotide-binding protein-like 3-like protein isoform X1

      UniProtKB/Swiss-Prot
      Q9NVN8

    RNA

    1. XR_008485483.1 RNA Sequence

    2. XR_008485484.1 RNA Sequence