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    POU3F2 POU class 3 homeobox 2 [ Homo sapiens (human) ]

    Gene ID: 5454, updated on 19-Jun-2024

    Summary

    Official Symbol
    POU3F2provided by HGNC
    Official Full Name
    POU class 3 homeobox 2provided by HGNC
    Primary source
    HGNC:HGNC:9215
    See related
    Ensembl:ENSG00000184486 MIM:600494; AllianceGenome:HGNC:9215
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BRN2; OCT7; OTF7; OTF-7; POUF3; brn-2; oct-7; N-Oct3
    Summary
    This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]
    Orthologs
    NEW
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    Genomic context

    See POU3F2 in Genome Data Viewer
    Location:
    6q16.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (98834574..98839458)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (100008944..100013827)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (99282450..99287334)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377910 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:98973520-98974100 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:98974101-98974679 Neighboring gene NANOG hESC enhancer GRCh37_chr6:98998595-98999096 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:99084768-99085311 Neighboring gene VISTA enhancer hs1085 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:99150974-99151146 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:99164203-99164752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:99235638-99236138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:99236139-99236639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:99273031-99273536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:99273537-99274042 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:99283167-99283763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:99283764-99284359 Neighboring gene uncharacterized LOC124901364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24851 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17412 Neighboring gene CRE2 CAGE-defined tissue-specific enhancer Neighboring gene long intergenic non-protein coding RNA PNKY Neighboring gene F-box and leucine rich repeat protein 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17413 Neighboring gene Sharpr-MPRA regulatory region 5946

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
    EBI GWAS Catalog
    Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
    EBI GWAS Catalog
    Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.
    EBI GWAS Catalog
    Genome-wide association study reveals two new risk loci for bipolar disorder.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cerebral cortex radially oriented cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epidermis development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in forebrain astrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in forebrain ventricular zone progenitor cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hypothalamus cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in myelination in peripheral nervous system IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuroendocrine cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neurohypophysis development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron fate specification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    POU domain, class 3, transcription factor 2
    Names
    brain-2
    brain-specific homeobox/POU domain protein 2
    nervous system-specific octamer-binding transcription factor N-Oct-3
    octamer-binding protein 7
    octamer-binding transcription factor 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005604.4NP_005595.2  POU domain, class 3, transcription factor 2

      See identical proteins and their annotated locations for NP_005595.2

      Status: REVIEWED

      Source sequence(s)
      AL022395, BC051699, DA491157
      Consensus CDS
      CCDS5040.1
      UniProtKB/Swiss-Prot
      P20265, Q14960, Q86V54, Q9UJL0
      Related
      ENSP00000329170.5, ENST00000328345.8
      Conserved Domains (2) summary
      smart00352
      Location:262336
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:357411
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      98834574..98839458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      100008944..100013827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)