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    Cep170 centrosomal protein 170 [ Mus musculus (house mouse) ]

    Gene ID: 545389, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cep170provided by MGI
    Official Full Name
    centrosomal protein 170provided by MGI
    Primary source
    MGI:MGI:1918348
    See related
    Ensembl:ENSMUSG00000057335 AllianceGenome:MGI:1918348
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933426L22Rik; A330004A13Rik
    Summary
    Located in centriole. Orthologous to human CEP170 (centrosomal protein 170). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 23.9), whole brain E14.5 (RPKM 21.2) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cep170 in Genome Data Viewer
    Location:
    1 H4; 1 82.6 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (176556638..176641545, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (176729072..176813979, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03117 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03118 Neighboring gene STARR-positive B cell enhancer ABC_E3336 Neighboring gene STARR-seq mESC enhancer starr_03119 Neighboring gene STARR-seq mESC enhancer starr_03120 Neighboring gene predicted gene, 26104 Neighboring gene STARR-positive B cell enhancer ABC_E10063 Neighboring gene STARR-positive B cell enhancer ABC_E10064 Neighboring gene microRNA 350 Neighboring gene STARR-positive B cell enhancer ABC_E3337 Neighboring gene serologically defined colon cancer antigen 8 Neighboring gene high mobility group AT-hook 2, pseudogene 1 Neighboring gene predicted gene, 38158 Neighboring gene STARR-positive B cell enhancer ABC_E5862 Neighboring gene predicted gene 15423

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    part_of centriolar subdistal appendage IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    centrosomal protein of 170 kDa
    Names
    KARP-1-binding protein
    centrosomal protein 170kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099637.2NP_001093107.2  centrosomal protein of 170 kDa isoform 1

      See identical proteins and their annotated locations for NP_001093107.2

      Status: VALIDATED

      Source sequence(s)
      AC113311, AC144905
      Consensus CDS
      CCDS48461.1
      UniProtKB/TrEMBL
      H7BX26
      Related
      ENSMUSP00000059562.7, ENSMUST00000057037.13
      Conserved Domains (2) summary
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:8021496
      CEP170_C; CEP170 C-terminus
    2. NM_001368872.1NP_001355801.1  centrosomal protein of 170 kDa isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113311, AC144905
      Conserved Domains (2) summary
      pfam15308
      Location:6551331
      CEP170_C; CEP170 C-terminus
      pfam00498
      Location:2389
      FHA; FHA domain
    3. NM_001368873.1NP_001355802.1  centrosomal protein of 170 kDa isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC113311
      Conserved Domains (2) summary
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:7041408
      CEP170_C; CEP170 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      176556638..176641545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152447.1XP_036008340.1  centrosomal protein of 170 kDa isoform X15

      Conserved Domains (2) summary
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:6671309
      CEP170_C; CEP170 C-terminus
    2. XM_036152446.1XP_036008339.1  centrosomal protein of 170 kDa isoform X14

      Conserved Domains (2) summary
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:6671319
      CEP170_C; CEP170 C-terminus
    3. XM_017321736.3XP_017177225.1  centrosomal protein of 170 kDa isoform X13

      Conserved Domains (2) summary
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:6541348
      CEP170_C; CEP170 C-terminus
    4. XM_006496947.4XP_006497010.1  centrosomal protein of 170 kDa isoform X11

      Conserved Domains (2) summary
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:7041372
      CEP170_C; CEP170 C-terminus
    5. XM_006496945.5XP_006497008.1  centrosomal protein of 170 kDa isoform X10

      Conserved Domains (2) summary
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:7041398
      CEP170_C; CEP170 C-terminus
    6. XM_036152443.1XP_036008336.1  centrosomal protein of 170 kDa isoform X7

      Conserved Domains (2) summary
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:7651443
      CEP170_C; CEP170 C-terminus
    7. XM_030255572.1XP_030111432.1  centrosomal protein of 170 kDa isoform X8

      Conserved Domains (2) summary
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:8021443
      CEP170_C; CEP170 C-terminus
    8. XM_030255571.1XP_030111431.1  centrosomal protein of 170 kDa isoform X5

      Conserved Domains (2) summary
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:8021460
      CEP170_C; CEP170 C-terminus
    9. XM_030255570.1XP_030111430.1  centrosomal protein of 170 kDa isoform X4

      Conserved Domains (2) summary
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:8021470
      CEP170_C; CEP170 C-terminus
    10. XM_030255569.1XP_030111429.1  centrosomal protein of 170 kDa isoform X3

      Conserved Domains (2) summary
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:8021479
      CEP170_C; CEP170 C-terminus
    11. XM_006496939.5XP_006497002.1  centrosomal protein of 170 kDa isoform X2

      See identical proteins and their annotated locations for XP_006497002.1

      UniProtKB/TrEMBL
      H7BX26
      Related
      ENSMUSP00000141769.2, ENSMUST00000195717.6
      Conserved Domains (2) summary
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:8021496
      CEP170_C; CEP170 C-terminus
    12. XM_006496937.4XP_006497000.1  centrosomal protein of 170 kDa isoform X1

      See identical proteins and their annotated locations for XP_006497000.1

      UniProtKB/Swiss-Prot
      Q6A065, Q7TQD9, Q8BJW2, Q9D3Z0
      Conserved Domains (2) summary
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:8021506
      CEP170_C; CEP170 C-terminus
    13. XM_006496940.5XP_006497003.1  centrosomal protein of 170 kDa isoform X2

      See identical proteins and their annotated locations for XP_006497003.1

      UniProtKB/TrEMBL
      H7BX26
      Conserved Domains (2) summary
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:8021496
      CEP170_C; CEP170 C-terminus
    14. XM_006496948.5XP_006497011.1  centrosomal protein of 170 kDa isoform X12

      Conserved Domains (2) summary
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:6541358
      CEP170_C; CEP170 C-terminus
    15. XM_006496944.5XP_006497007.1  centrosomal protein of 170 kDa isoform X9

      Conserved Domains (2) summary
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:7041408
      CEP170_C; CEP170 C-terminus
    16. XM_006496943.5XP_006497006.1  centrosomal protein of 170 kDa isoform X6

      Conserved Domains (2) summary
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:7521456
      CEP170_C; CEP170 C-terminus
    17. XM_030255566.2XP_030111426.1  centrosomal protein of 170 kDa isoform X1

      UniProtKB/Swiss-Prot
      Q6A065, Q7TQD9, Q8BJW2, Q9D3Z0
      Related
      ENSMUSP00000141793.2, ENSMUST00000194727.6
      Conserved Domains (2) summary
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:8021506
      CEP170_C; CEP170 C-terminus

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024722.1: Suppressed sequence

      Description
      NM_001024722.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.