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    Iqgap2 IQ motif containing GTPase activating protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 544963, updated on 23-Jun-2021

    Summary

    Official Symbol
    Iqgap2provided by MGI
    Official Full Name
    IQ motif containing GTPase activating protein 2provided by MGI
    Primary source
    MGI:MGI:2449975
    See related
    Ensembl:ENSMUSG00000021676
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI788777; A630053O10; 4933417J23Rik
    Expression
    Broad expression in placenta adult (RPKM 18.9), liver E18 (RPKM 15.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Iqgap2 in Genome Data Viewer
    Location:
    13 D1; 13 50.26 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (95763685..96028788, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (95627177..95892280, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (96397132..96661877, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32640 Neighboring gene coagulation factor II (thrombin) receptor Neighboring gene predicted gene, 33074 Neighboring gene predicted gene, 48745 Neighboring gene predicted gene, 52062 Neighboring gene coagulation factor II (thrombin) receptor-like 2 Neighboring gene predicted gene, 32702 Neighboring gene predicted gene, 24032 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene synaptic vesicle glycoprotein 2c

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Arp2/3 complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thrombin-activated receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ras GTPase-activating-like protein IQGAP2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027711.1NP_081987.1  ras GTPase-activating-like protein IQGAP2

      See identical proteins and their annotated locations for NP_081987.1

      Status: VALIDATED

      Source sequence(s)
      AK142813, AK147360, CJ201339
      Consensus CDS
      CCDS36753.1
      UniProtKB/Swiss-Prot
      Q3UQ44
      Related
      ENSMUSP00000067685.7, ENSMUST00000068603.8
      Conserved Domains (5) summary
      smart00015
      Location:689710
      IQ; Calmodulin-binding motif
      cd05131
      Location:9161274
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      smart00323
      Location:9051257
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00014
      Location:42156
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam03836
      Location:13671498
      RasGAP_C; RasGAP C-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      95763685..96028788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158092.1XP_036013985.1  ras GTPase-activating-like protein IQGAP2 isoform X2

      Conserved Domains (4) summary
      smart00015
      Location:726747
      IQ; Calmodulin-binding motif
      cd05131
      Location:9531311
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      COG5261
      Location:8211606
      IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
      cl00030
      Location:53203
      CH_SF; calponin homology (CH) domain superfamily
    2. XM_036158091.1XP_036013984.1  ras GTPase-activating-like protein IQGAP2 isoform X1

      Conserved Domains (4) summary
      smart00015
      Location:726747
      IQ; Calmodulin-binding motif
      cd05131
      Location:9531311
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      COG5261
      Location:8211612
      IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
      cl00030
      Location:53203
      CH_SF; calponin homology (CH) domain superfamily
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