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    OTULINL OTU deubiquitinase with linear linkage specificity like [ Homo sapiens (human) ]

    Gene ID: 54491, updated on 3-Nov-2024

    Summary

    Official Symbol
    OTULINLprovided by HGNC
    Official Full Name
    OTU deubiquitinase with linear linkage specificity likeprovided by HGNC
    Primary source
    HGNC:HGNC:25629
    See related
    Ensembl:ENSG00000145569 AllianceGenome:HGNC:25629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NET20; FAM105A
    Summary
    Located in cytoplasmic side of endoplasmic reticulum membrane and nuclear envelope. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bone marrow (RPKM 12.7), colon (RPKM 9.2) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See OTULINL in Genome Data Viewer
    Location:
    5p15.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (14581792..14616180)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (14520844..14555231)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (14581901..14616289)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene trio Rho guanine nucleotide exchange factor Neighboring gene uncharacterized LOC124900943 Neighboring gene OCT4 hESC enhancer GRCh37_chr5:14346974-14347475 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:14358109-14358798 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:14399912-14401111 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:14406263-14407462 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:14417547-14418093 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:14445485-14446012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:14446013-14446539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22401 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22403 Neighboring gene Sharpr-MPRA regulatory region 14564 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:14465686-14465857 Neighboring gene small nucleolar RNA, C/D box 170 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:14497716-14498915 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:14521506-14522006 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:14522007-14522507 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:14577633-14578133 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15941 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22404 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22406 Neighboring gene pleckstrin homology domain containing A1 pseudogene Neighboring gene chaperonin containing TCP1 subunit 6 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    inactive ubiquitin thioesterase OTULINL
    Names
    family with sequence similarity 105 member A
    inactive ubiquitin thioesterase FAM105A
    protein FAM105A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019018.3NP_061891.1  inactive ubiquitin thioesterase OTULINL

      See identical proteins and their annotated locations for NP_061891.1

      Status: VALIDATED

      Source sequence(s)
      AC010627, AF052146, BC011524, BX342178
      Consensus CDS
      CCDS3884.1
      UniProtKB/Swiss-Prot
      Q53H50, Q9H037, Q9NUU6
      Related
      ENSP00000274217.3, ENST00000274217.4
      Conserved Domains (1) summary
      pfam16218
      Location:89355
      Peptidase_C101; Peptidase family C101

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      14581792..14616180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417322.1XP_047273278.1  inactive ubiquitin thioesterase OTULINL isoform X1

    2. XM_047417323.1XP_047273279.1  inactive ubiquitin thioesterase OTULINL isoform X1

    3. XM_047417324.1XP_047273280.1  inactive ubiquitin thioesterase OTULINL isoform X2

    RNA

    1. XR_925623.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      14520844..14555231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352834.1XP_054208809.1  inactive ubiquitin thioesterase OTULINL isoform X1

    2. XM_054352835.1XP_054208810.1  inactive ubiquitin thioesterase OTULINL isoform X1

    3. XM_054352836.1XP_054208811.1  inactive ubiquitin thioesterase OTULINL isoform X2

    RNA

    1. XR_008487126.1 RNA Sequence