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    UGT2B28 UDP glucuronosyltransferase family 2 member B28 [ Homo sapiens (human) ]

    Gene ID: 54490, updated on 27-Nov-2024

    Summary

    Official Symbol
    UGT2B28provided by HGNC
    Official Full Name
    UDP glucuronosyltransferase family 2 member B28provided by HGNC
    Primary source
    HGNC:HGNC:13479
    See related
    Ensembl:ENSG00000135226 MIM:606497; AllianceGenome:HGNC:13479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Two transcript variants encoding different isoforms have been found for this gene. While both isoforms are targeted to the endoplasmic reticulum, only the longer isoform appears to be active. [provided by RefSeq, May 2011]
    Expression
    Biased expression in gall bladder (RPKM 10.0) and salivary gland (RPKM 0.9) See more
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    Genomic context

    See UGT2B28 in Genome Data Viewer
    Location:
    4q13.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (69280475..69295050)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70146193..70160768)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377267 Neighboring gene UDP glucuronosyltransferase family 2 member B11 Neighboring gene UDP glucuronosyltransferase family 2 member B4 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr4:70205243-70205778 Neighboring gene MPRA-validated peak5052 silencer Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glucuronosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glucuronosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular glucuronidation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in estrogen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in steroid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in xenobiotic glucuronidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    UDP-glucuronosyltransferase 2B28
    Names
    UDP glucuronosyltransferase 2 family, polypeptide B28
    UDP glycosyltransferase 2 family, polypeptide B28
    UDPGT 2B28
    NP_001193933.1
    NP_444267.1
    XP_016863792.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029527.1 RefSeqGene

      Range
      4977..19552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001207004.2NP_001193933.1  UDP-glucuronosyltransferase 2B28 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001193933.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two coding exons compared to variant 1, that causes a frameshift.The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC114786, AF177273
      Consensus CDS
      CCDS56330.1
      UniProtKB/Swiss-Prot
      Q9BY64
      Related
      ENSP00000427399.1, ENST00000511240.1
      Conserved Domains (2) summary
      pfam00201
      Location:24335
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
      cl10013
      Location:26333
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    2. NM_053039.2NP_444267.1  UDP-glucuronosyltransferase 2B28 isoform 1 precursor

      See identical proteins and their annotated locations for NP_444267.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC114786, AF177272
      Consensus CDS
      CCDS3528.1
      UniProtKB/Swiss-Prot
      B5BUM0, Q9BY62, Q9BY63, Q9BY64
      Related
      ENSP00000334276.5, ENST00000335568.10
      Conserved Domains (2) summary
      PHA03392
      Location:269506
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:24525
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      69280475..69295050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008303.2XP_016863792.1  UDP-glucuronosyltransferase 2B28 isoform X1