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    ATAD2B ATPase family AAA domain containing 2B [ Homo sapiens (human) ]

    Gene ID: 54454, updated on 9-Dec-2022

    Summary

    Official Symbol
    ATAD2Bprovided by HGNC
    Official Full Name
    ATPase family AAA domain containing 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:29230
    See related
    Ensembl:ENSG00000119778 MIM:615347; AllianceGenome:HGNC:29230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene belongs to the AAA ATPase family. This family member includes an N-terminal bromodomain. It has been found to be localized to the nucleus, partly to replication sites, consistent with a chromatin-related function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Expression
    Ubiquitous expression in lymph node (RPKM 1.9), testis (RPKM 1.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ATAD2B in Genome Data Viewer
    Location:
    2p24.1-p23.3
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (23677969..23927123, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (23783746..23961815, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (23971534..24149993, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene kelch like family member 29 Neighboring gene uncharacterized LOC105374325 Neighboring gene uncharacterized LOC102723401 Neighboring gene phosphoglycerate mutase 1 pseudogene 6 Neighboring gene ribosomal protein S13 pseudogene 4 Neighboring gene UBX domain protein 2A Neighboring gene succinate dehydrogenase complex subunit C pseudogene 3 Neighboring gene RNA, 7SL, cytoplasmic 610, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1240, MGC88424

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lysine-acetylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ATPase family AAA domain-containing protein 2B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029017.3 RefSeqGene

      Range
      5000..183459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001242338.3NP_001229267.2  ATPase family AAA domain-containing protein 2B isoform 2

      Status: REVIEWED

      Source sequence(s)
      AB033066, AC066692, AK094821, BC171846, BM974506
      UniProtKB/Swiss-Prot
      Q9ULI0
      Conserved Domains (4) summary
      cd05528
      Location:9601066
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      smart00382
      Location:433574
      AAA; ATPases associated with a variety of cellular activities
      COG5076
      Location:8521081
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00004
      Location:438572
      AAA; ATPase family associated with various cellular activities (AAA)
    2. NM_001354107.2NP_001341036.1  ATPase family AAA domain-containing protein 2B isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC009242, AC066692, AC079924, BM974506, KF456640
      Conserved Domains (2) summary
      cd05528
      Location:9741080
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      cl27568
      Location:411683
      TIP49; TIP49 C-terminus
    3. NM_017552.4NP_060022.2  ATPase family AAA domain-containing protein 2B isoform 1

      Status: REVIEWED

      Source sequence(s)
      AB033066, AC066692, AK094821, AK125718, BC171846, BM974506
      Consensus CDS
      CCDS46227.1
      UniProtKB/Swiss-Prot
      Q9ULI0
      UniProtKB/TrEMBL
      B3KWS5
      Related
      ENSP00000238789.5, ENST00000238789.10
      Conserved Domains (4) summary
      cd05528
      Location:9601071
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      smart00382
      Location:433574
      AAA; ATPases associated with a variety of cellular activities
      COG5076
      Location:8521086
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00004
      Location:438572
      AAA; ATPase family associated with various cellular activities (AAA)

    RNA

    1. NR_125717.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AB033066, AC066692, AK094821, BC171846, BM974506

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      23677969..23927123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444799.1XP_047300755.1  ATPase family AAA domain-containing protein 2B isoform X1

    2. XM_006712030.5XP_006712093.1  ATPase family AAA domain-containing protein 2B isoform X6

      Conserved Domains (4) summary
      cd05528
      Location:9741085
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      smart00382
      Location:447588
      AAA; ATPases associated with a variety of cellular activities
      COG5076
      Location:8661100
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00004
      Location:452586
      AAA; ATPase family associated with various cellular activities (AAA)
    3. XM_011532920.4XP_011531222.1  ATPase family AAA domain-containing protein 2B isoform X4

      Conserved Domains (4) summary
      cd05528
      Location:9601071
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      smart00382
      Location:433574
      AAA; ATPases associated with a variety of cellular activities
      COG5076
      Location:8521086
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00004
      Location:438572
      AAA; ATPase family associated with various cellular activities (AAA)
    4. XM_011532919.4XP_011531221.1  ATPase family AAA domain-containing protein 2B isoform X3

      Conserved Domains (4) summary
      cd05528
      Location:9741080
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      smart00382
      Location:447588
      AAA; ATPases associated with a variety of cellular activities
      COG5076
      Location:8661095
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00004
      Location:452586
      AAA; ATPase family associated with various cellular activities (AAA)
    5. XM_011532918.4XP_011531220.1  ATPase family AAA domain-containing protein 2B isoform X2

      Conserved Domains (4) summary
      cd05528
      Location:9741085
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      smart00382
      Location:447588
      AAA; ATPases associated with a variety of cellular activities
      COG5076
      Location:8661100
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00004
      Location:452586
      AAA; ATPase family associated with various cellular activities (AAA)
    6. XM_005264372.5XP_005264429.2  ATPase family AAA domain-containing protein 2B isoform X5

      Conserved Domains (4) summary
      cd05528
      Location:9741085
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      smart00382
      Location:447588
      AAA; ATPases associated with a variety of cellular activities
      COG5076
      Location:8661100
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00004
      Location:452586
      AAA; ATPase family associated with various cellular activities (AAA)
    7. XM_011532924.4XP_011531226.1  ATPase family AAA domain-containing protein 2B isoform X7

      Conserved Domains (3) summary
      cd05528
      Location:9741059
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      smart00382
      Location:447588
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:452586
      AAA; ATPase family associated with various cellular activities (AAA)
    8. XM_011532925.4XP_011531227.1  ATPase family AAA domain-containing protein 2B isoform X8

      Conserved Domains (3) summary
      cd05528
      Location:9741059
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      smart00382
      Location:447588
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:452586
      AAA; ATPase family associated with various cellular activities (AAA)
    9. XM_047444801.1XP_047300757.1  ATPase family AAA domain-containing protein 2B isoform X11

    10. XM_047444800.1XP_047300756.1  ATPase family AAA domain-containing protein 2B isoform X10

    11. XM_006712031.5XP_006712094.1  ATPase family AAA domain-containing protein 2B isoform X9

      Conserved Domains (3) summary
      cd05528
      Location:9741058
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      smart00382
      Location:447588
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:452586
      AAA; ATPase family associated with various cellular activities (AAA)
    12. XM_047444803.1XP_047300759.1  ATPase family AAA domain-containing protein 2B isoform X13

    13. XM_047444802.1XP_047300758.1  ATPase family AAA domain-containing protein 2B isoform X12

    14. XM_011532928.3XP_011531230.1  ATPase family AAA domain-containing protein 2B isoform X14

      See identical proteins and their annotated locations for XP_011531230.1

      Conserved Domains (2) summary
      smart00382
      Location:447588
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:452586
      AAA; ATPase family associated with various cellular activities (AAA)
    15. XM_011532929.4XP_011531231.1  ATPase family AAA domain-containing protein 2B isoform X15

      Conserved Domains (2) summary
      smart00382
      Location:447588
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:452586
      AAA; ATPase family associated with various cellular activities (AAA)
    16. XM_011532931.4XP_011531233.1  ATPase family AAA domain-containing protein 2B isoform X17

      Conserved Domains (2) summary
      smart00382
      Location:447588
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:452586
      AAA; ATPase family associated with various cellular activities (AAA)
    17. XM_047444804.1XP_047300760.1  ATPase family AAA domain-containing protein 2B isoform X14

    18. XM_047444805.1XP_047300761.1  ATPase family AAA domain-containing protein 2B isoform X18

    19. XM_011532930.4XP_011531232.1  ATPase family AAA domain-containing protein 2B isoform X16

      Conserved Domains (2) summary
      smart00382
      Location:447588
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:452586
      AAA; ATPase family associated with various cellular activities (AAA)
    20. XM_047444806.1XP_047300762.1  ATPase family AAA domain-containing protein 2B isoform X20

    21. XM_011532932.3XP_011531234.1  ATPase family AAA domain-containing protein 2B isoform X19

      See identical proteins and their annotated locations for XP_011531234.1

      Conserved Domains (2) summary
      smart00382
      Location:447588
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:452586
      AAA; ATPase family associated with various cellular activities (AAA)
    22. XM_047444808.1XP_047300764.1  ATPase family AAA domain-containing protein 2B isoform X22

    23. XM_047444807.1XP_047300763.1  ATPase family AAA domain-containing protein 2B isoform X21

    RNA

    1. XR_001738780.3 RNA Sequence

    2. XR_001738782.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      23783746..23961815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)