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    Dnmt3l DNA (cytosine-5-)-methyltransferase 3-like [ Mus musculus (house mouse) ]

    Gene ID: 54427, updated on 6-Sep-2021

    Summary

    Official Symbol
    Dnmt3lprovided by MGI
    Official Full Name
    DNA (cytosine-5-)-methyltransferase 3-likeprovided by MGI
    Primary source
    MGI:MGI:1859287
    See related
    Ensembl:ENSMUSG00000000730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ecat; ecat7; D6Ertd14; D6Ertd14e
    Summary
    CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein that is a catalytically inactive regulatory factor of DNA methyltransferases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in bladder adult (RPKM 7.4), testis adult (RPKM 3.8) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Dnmt3l in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (77878121..77899456)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (78042287..78063622)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (77505032..77526360)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 410 Neighboring gene phosphofructokinase, liver, B-type Neighboring gene autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) Neighboring gene predicted gene, 51775 Neighboring gene icos ligand Neighboring gene predicted gene, 47922

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (7)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102308

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables enzyme regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA methylation involved in gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA methylation on cytosine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chorionic trophoblast cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within genetic imprinting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transposition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA (cytosine-5)-methyltransferase 3-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081695.2NP_001075164.1  DNA (cytosine-5)-methyltransferase 3-like isoform 1

      See identical proteins and their annotated locations for NP_001075164.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is expressed in ovary (PMID: 17060371). It differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform 1.
      Source sequence(s)
      AV511576, EF051624
      Consensus CDS
      CCDS23962.1
      UniProtKB/Swiss-Prot
      Q9CWR8
      UniProtKB/TrEMBL
      A3EWM2
      Related
      ENSMUSP00000121562.2, ENSMUST00000138785.8
      Conserved Domains (1) summary
      cl22851
      Location:81203
      PHD_SF; PHD finger superfamily
    2. NM_001284197.1NP_001271126.1  DNA (cytosine-5)-methyltransferase 3-like isoform 1

      See identical proteins and their annotated locations for NP_001271126.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is expressed in testis, thymus, ovary, and heart, as well as in 7-day, 15-day, and 17-day embryo (PMID: 11306809). It differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform 1.
      Source sequence(s)
      AF220524, AV473569, AV511576
      Consensus CDS
      CCDS23962.1
      UniProtKB/Swiss-Prot
      Q9CWR8
      UniProtKB/TrEMBL
      A3EWM2
      Related
      ENSMUSP00000116970.2, ENSMUST00000151242.8
      Conserved Domains (1) summary
      cl22851
      Location:81203
      PHD_SF; PHD finger superfamily
    3. NM_001284198.1NP_001271127.1  DNA (cytosine-5)-methyltransferase 3-like isoform 2

      See identical proteins and their annotated locations for NP_001271127.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) is expressed in testis (PMID: 17060371). It contains alternate 5' UTR exons, lacks a portion of the 5' coding region, and initiates translation at a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 4, 5 and 6 encode the same isoform (2).
      Source sequence(s)
      AV511576, EF051621
      Consensus CDS
      CCDS70061.1
      UniProtKB/TrEMBL
      D3YUQ4
      Related
      ENSMUSP00000123015.2, ENSMUST00000123940.2
    4. NM_001284199.1NP_001271128.1  DNA (cytosine-5)-methyltransferase 3-like isoform 2

      See identical proteins and their annotated locations for NP_001271128.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) is expressed in testis (PMID: 17060371). It contains alternate 5' UTR exons, lacks a portion of the 5' coding region, and initiates translation at a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 4, 5 and 6 encode the same isoform (2).
      Source sequence(s)
      AV511576, EF051622
      Consensus CDS
      CCDS70061.1
      UniProtKB/TrEMBL
      D3YUQ4
      Related
      ENSMUSP00000117827.2, ENSMUST00000139539.8
    5. NM_001284200.1NP_001271129.1  DNA (cytosine-5)-methyltransferase 3-like isoform 2

      See identical proteins and their annotated locations for NP_001271129.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) is expressed in testis (PMID: 17060371). It contains alternate 5' UTR exons, lacks a portion of the 5' coding region, and initiates translation at a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 4, 5 and 6 encode the same isoform (2).
      Source sequence(s)
      AV511576, EF051623
      Consensus CDS
      CCDS70061.1
      UniProtKB/TrEMBL
      D3YUQ4
      Related
      ENSMUSP00000119571.2, ENSMUST00000131825.8
    6. NM_019448.4NP_062321.1  DNA (cytosine-5)-methyltransferase 3-like isoform 1

      See identical proteins and their annotated locations for NP_062321.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is expressed in prospermatogonia (PMID: 17060371). It encodes the longer isoform (1). Variants 1, 2 and 3 encode the same isoform 1.
      Source sequence(s)
      AK010434, AV511576
      Consensus CDS
      CCDS23962.1
      UniProtKB/Swiss-Prot
      Q9CWR8
      UniProtKB/TrEMBL
      A3EWM2
      Related
      ENSMUSP00000000746.6, ENSMUST00000000746.12
      Conserved Domains (1) summary
      cl22851
      Location:81203
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      77878121..77899456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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