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    Fmn2 formin 2 [ Mus musculus (house mouse) ]

    Gene ID: 54418, updated on 2-Oct-2018

    Summary

    Official Symbol
    Fmn2provided by MGI
    Official Full Name
    formin 2provided by MGI
    Primary source
    MGI:MGI:1859252
    See related
    Ensembl:ENSMUSG00000028354 Vega:OTTMUSG00000050244
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU024104
    Expression
    Biased expression in frontal lobe adult (RPKM 7.4), cortex adult (RPKM 7.0) and 6 other tissues See more
    Orthologs

    Genomic context

    See Fmn2 in Genome Data Viewer
    Location:
    1 H3; 1 81.04 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (174501825..174822729)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (176431956..176752860)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene olfactory receptor 414 Neighboring gene olfactory receptor 220 Neighboring gene lines homolog 2 pseudogene Neighboring gene gremlin 2, DAN family BMP antagonist Neighboring gene regulator of G protein signaling 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of meiotic spindle localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    formin-nucleated actin cable assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    formin-nucleated actin cable assembly ISO
    Inferred from Sequence Orthology
    more info
     
    homologous chromosome movement towards spindle pole involved in homologous chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    meiotic chromosome movement towards spindle pole IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    polar body extrusion after meiotic divisions IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament IEA
    Inferred from Electronic Annotation
    more info
     
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019445.2NP_062318.2  formin-2

      See identical proteins and their annotated locations for NP_062318.2

      Status: VALIDATED

      Source sequence(s)
      BC094606, BM228488, BP758042
      Consensus CDS
      CCDS48459.1
      UniProtKB/Swiss-Prot
      Q9JL04
      Related
      ENSMUSP00000030039.7, OTTMUSP00000068822, ENSMUST00000030039.12, OTTMUST00000127630
      Conserved Domains (1) summary
      pfam02181
      Location:11391529
      FH2; Formin Homology 2 Domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      174501825..174822729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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