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    Phc2 polyhomeotic 2 [ Mus musculus (house mouse) ]

    Gene ID: 54383, updated on 23-Jun-2021

    Summary

    Official Symbol
    Phc2provided by MGI
    Official Full Name
    polyhomeotic 2provided by MGI
    Primary source
    MGI:MGI:1860454
    See related
    Ensembl:ENSMUSG00000028796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Edr; Mph; p36; Edr2; Mph2; A3galt2; AA415044; D4Ertd810; D4Ertd810e; D130050K19Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 25.0), ovary adult (RPKM 24.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Phc2 in Genome Data Viewer
    Location:
    4 D2.2; 4 62.12 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (128548448..128646674)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (128654655..128752881)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (128382240..128430118)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene toll-like receptor 12 Neighboring gene predicted gene 12958 Neighboring gene VISTA enhancer mm1684 Neighboring gene predicted gene, 33712 Neighboring gene alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase) Neighboring gene zinc finger protein 362 Neighboring gene predicted gene, 52679

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of PRC1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of PcG protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    polyhomeotic-like protein 2
    Names
    early development regulator 2
    early development regulatory protein 2
    polyhomeotic 2 protein
    polyhomeotic-like 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195083.1NP_001182012.1  polyhomeotic-like protein 2 isoform B

      See identical proteins and their annotated locations for NP_001182012.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks 8 coding exons in the 5' region, and initiates translation at a downstream AUG, compared to variant 1. The resulting protein (isoform B) has a shorter N-terminus, compared to isoform A.
      Source sequence(s)
      AL611983
      Consensus CDS
      CCDS57297.1
      UniProtKB/Swiss-Prot
      Q9QWH1
      Related
      ENSMUSP00000101689.4, ENSMUST00000106079.10
      Conserved Domains (2) summary
      cd09577
      Location:254322
      SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
      pfam16616
      Location:135254
      PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2
    2. NM_001195130.1NP_001182059.1  polyhomeotic-like protein 2 isoform A

      See identical proteins and their annotated locations for NP_001182059.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein (isoform A).
      Source sequence(s)
      AL611969, AL611983
      Consensus CDS
      CCDS18674.1
      UniProtKB/Swiss-Prot
      Q9QWH1
      Related
      ENSMUSP00000030588.7, ENSMUST00000030588.13
      Conserved Domains (3) summary
      cd09577
      Location:781849
      SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
      PHA03247
      Location:216540
      PHA03247; large tegument protein UL36; Provisional
      pfam16616
      Location:662780
      PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2
    3. NM_018774.4NP_061244.1  polyhomeotic-like protein 2 isoform A

      See identical proteins and their annotated locations for NP_061244.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (A). Both variants 1 and 2 encode the same protein (isoform A).
      Source sequence(s)
      AL611969, BC057571, BE995150
      Consensus CDS
      CCDS18674.1
      UniProtKB/Swiss-Prot
      Q9QWH1
      Related
      ENSMUSP00000101690.2, ENSMUST00000106080.8
      Conserved Domains (3) summary
      cd09577
      Location:781849
      SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
      PHA03247
      Location:216540
      PHA03247; large tegument protein UL36; Provisional
      pfam16616
      Location:662780
      PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      128548448..128646674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240576.4XP_011238878.1  polyhomeotic-like protein 2 isoform X3

      Conserved Domains (1) summary
      PHA03247
      Location:216499
      PHA03247; large tegument protein UL36; Provisional
    2. XM_006503234.3XP_006503297.1  polyhomeotic-like protein 2 isoform X2

      Conserved Domains (3) summary
      cd09577
      Location:752820
      SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
      PHA03247
      Location:219511
      PHA03247; large tegument protein UL36; Provisional
      pfam16616
      Location:633751
      PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2
    3. XM_017320320.1XP_017175809.1  polyhomeotic-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9QWH1
      Conserved Domains (3) summary
      cd09577
      Location:781849
      SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
      PHA03247
      Location:216540
      PHA03247; large tegument protein UL36; Provisional
      pfam16616
      Location:662780
      PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2
    4. XM_036164241.1XP_036020134.1  polyhomeotic-like protein 2 isoform X5

      Conserved Domains (2) summary
      cd09577
      Location:254322
      SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
      pfam16616
      Location:135254
      PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2
    5. XM_006503236.1XP_006503299.1  polyhomeotic-like protein 2 isoform X4

      Conserved Domains (2) summary
      cd09577
      Location:296364
      SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
      pfam16616
      Location:177295
      PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2
    6. XM_006503238.1XP_006503301.1  polyhomeotic-like protein 2 isoform X5

      See identical proteins and their annotated locations for XP_006503301.1

      UniProtKB/Swiss-Prot
      Q9QWH1
      Conserved Domains (2) summary
      cd09577
      Location:254322
      SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
      pfam16616
      Location:135254
      PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2

    RNA

    1. XR_376334.4 RNA Sequence

    2. XR_004941936.1 RNA Sequence

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